Cure8 research brief
Why This Matters
Older adults with IBD are under-represented in trials, so age-specific benefits and harms of newer oral drugs (JAK inhibitors and S1P modulators) are uncertain. Clinicians and patients may need to weigh efficacy against age-related safety risks and frailty when choosing therapy.
Who Should Pay Attention
Older adults with IBD, caregivers, gastroenterologists, primary care clinicians, researchers in IBD therapeutics and pharmacovigilance
Study Snapshot
What To Know
This paper reviews published studies rather than presenting new trial results. It maps available age-specific findings for JAK inhibitors and S1P modulators used in IBD and highlights gaps: older adults are underrepresented and data are sparse and inconsistent.
The review notes that while clinical and endoscopic efficacy is often similar across ages in the limited datasets, older patients may face higher risks related to infections, major cardiovascular events, thromboembolism and malignancy signals—risks that can be amplified by comorbidity, frailty and polypharmacy.
The authors emphasise using frailty and organ-function assessments to guide treatment choice and applying structured risk-mitigation when prescribing these oral agents to older adults.
Keep In Mind
This is a narrative review abstract from a peer-reviewed journal (Drugs & Aging). The authors emphasise sparse, heterogeneous age-stratified data and recommend future prospective, frailty-focused research and long-term pharmacovigilance.
Source Details
Review the original publication for the complete reporting, methods, and context.
Conflict statement: Declarations. Conflict of interest: Luc J.J. Derijks has served as a speaker for AbbVie, Celltrion, Janssen-Cilag and Takeda and has developed continuing education materials for Ferring, all outside the submitted work. Fatma Karapinar-Çarkit has no conflicts of interest that are directly relevant to the content of this article. Zlatan Mujagić received grants from ZonMw, Niels Stensen Fellowship, MLDS, Top consortium for Knowledge and Innovation (TKI) and Galapagos; advisory board fees from Johnson & Johnson, Eli Lilly and Pfizer (paid to host institution)l and speaker’s fees from Friso-Friesland Campina, Galapagos, Eli Lilly and Takeda (paid to host institution), all outside the submitted work. Rob J. van Marum has no conflicts of interest that are directly relevant to the content of this article. Marieke J. Pierik has received grants from Falk Pharma, the European Commission, ZonMw, Takeda, Johnson & Johnson and AbbVie and non-financial support from Falk Pharma, Takeda, Johnson & Johnson, AbbVie, Ferring, Immunodiagnostics and MSD, all outside the submitted work. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Availability of data and material: Not applicable. Code availability: Not applicable. Author contributions: LD accepted the invitation and wrote the manuscript. All authors contributed to the drafting and critical revision of the manuscript and approved the final version of this manuscript.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.