Latest IBD News

People with Crohn's disease who develop symptomatic intestinal strictures currently often need endoscopic dilation or surgery. This trial tests an investigational oral drug (ontunisertib) aiming to improve...

A rapid stool molecular test could offer a noninvasive way to measure inflammation, predict relapse, and monitor treatment response in children with IBD—areas where current tests have limitations.

A pediatric Phase 2 trial testing etrasimod could expand treatment options for children with moderately to severely active ulcerative colitis if later shown safe and effective. Families of affected children and their...

Perianal fistulas are a serious, common complication of Crohn's disease that are often difficult to heal. This study tests a real-world combination of surgery plus an approved IL-23 inhibitor (mirikizumab) to see if...

Early-phase mechanistic trials test how a new drug affects disease biology and safety; results can help decide whether larger trials should follow.

The study identifies a molecular link between epithelial mitochondrial oxidative stress and NLRP3-driven inflammation in ulcerative colitis models, suggesting a possible new target for research into disease mechanisms...

If validated, an imaging-derived adipose heterogeneity biomarker could help predict who will lose response to infliximab after induction, potentially guiding earlier treatment decisions and personalized monitoring for...

Cure8 found this source from Alimentary pharmacology & therapeutics, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease. Open the original...

Growth and nutrition are common concerns in children with IBD because poor weight gain and short stature can affect long‑term health and development.

Cure8 found this source from Journal of paediatrics and child health, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Upadacitinib. Open the original...

This paper explores whether individualized integrative management including traditional Chinese medicine might influence outcomes in patients with biologic‑refractory, surgery‑intended acute severe ulcerative colitis — a...

The study points to three bile-acid–related genes that may be linked to inflammation in ulcerative colitis and could serve as biomarkers or targets for future research into disease mechanisms and patient stratification.

Treg/Th17 balance is a central immune mechanism implicated in IBD pathogenesis; understanding how microbes, metabolites, and tissue context control that balance could inform new biomarkers and targeted therapies.

The study links TXNIP/NLRP3 inflammatory signaling to disease features in an animal UC model and tests engeletin and rosuvastatin as interventions that lowered inflammatory markers—information relevant to researchers...

Colon-targeted delivery systems aim to concentrate drugs in the colon, which could improve effectiveness and reduce systemic side effects for IBD and colorectal cancer treatments. Understanding these approaches helps...

This review summarizes human evidence that pesticides in the diet could affect the gut microbiome and may be linked to gastrointestinal outcomes including IBD; strongest consistent signals were for organochlorine...

The study links activation of the cGAS–STING immune-sensing pathway to NF-κB–driven inflammation and tumor formation in UC models, which could help explain mechanisms behind colitis-associated colorectal cancer risk.

The work aims to predict relapse and personalize herbal maintenance dosing for UC, which matters because better risk stratification and tailored management could reduce relapses and avoid unnecessary treatment changes.

This animal study suggests date palm pollen extract reduced inflammation and tissue damage in a rat model of colitis, which could point to new lines of research into dietary supplements or natural compounds for gut...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and CRP. The original article is from Alimentary Pharmacology & Therapeutics.

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease. The original article is from Alimentary Pharmacology &...

People with ulcerative colitis may be interested because the study describes a natural compound that reduced inflammation and disease signs in a mouse model and acted through the gut microbiota and immune pathways —...

The study identifies miR-23b-3p as elevated in UC and CD and linked to disease severity, and shows in cell models that lowering miR-23b-3p can improve epithelial barrier function via Erbin. If confirmed, this miRNA could...

The study suggests a rice bran plus feruloyl-esterase–producing bacterium reduced inflammation and tissue injury in a mouse model of ulcerative colitis, pointing to a possible diet–microbiome approach worth further...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Food Bioscience.

A formulation that keeps budesonide at the colon surface longer and protects the mucosa could enhance topical treatment for ulcerative colitis and improve mucosal healing compared with standard enemas.

This study explores a potential target (the apelin receptor) that may affect intestinal barrier health in inflammatory bowel disease, which is relevant because barrier dysfunction contributes to flares and systemic...

The study links NAD+ precursor (NMN) supplementation to changes in TGF-β–associated gene programs, intestinal immune signatures, and the gut microbiome in mouse colitis models — pathways relevant to fibrosis and...

Perceived stigma may affect how Black people with IBD view their care and whether they stick with medications, which can influence disease management and outcomes. Understanding these links can point to targets for...

IBD-U means no clear Crohn’s or ulcerative colitis diagnosis yet — that uncertainty can affect treatment decisions and follow-up. The review highlights tests that may help clarify diagnosis and stresses that many...

Some cancers of the small intestine can look like Crohn’s disease. If symptoms don’t fit typical IBD patterns or don’t respond as expected to therapy, re-evaluation may be needed to avoid delays in diagnosis and...

People with UC often look for dietary supplements or ‘‘natural’’ add-ons. This review explains which nutraceutical approaches have the most and least clinical support, helping patients and clinicians weigh potential...

The paper links common tire-derived pollutants to intestinal injury and pathways also implicated in Crohn’s disease and ulcerative colitis, suggesting environmental chemicals could influence gut inflammation. If...

The study describes a mechanism by which Huaier granules reduced colitis-related inflammation in mice and cell models by targeting macrophage cGAS–STING signaling and altering the gut microbiome—information that could...

People with pediatric IBD-like intestinal inflammation, or caregivers, may encounter overlapping autoimmune conditions such as large-vessel vasculitis; recognizing that intestinal biopsy can be nondiagnostic is...

Pharmacokinetics affect how well biologic drugs work for IBD. Better PK data could help explain why many patients have inadequate responses and could inform personalized dosing for IL-23p19 inhibitors used in Crohn’s...

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Community and awareness. The original article is from Iraqi Journal of Pharmacy.

The study identifies a gut bacterial metabolite that appears to reduce intestinal inflammation through SIRT1 stabilization and macrophage metabolic reprogramming — a potential new biological pathway relevant to Crohn’s...

Researchers are exploring a gut microbe–derived lipid (SoL A) that may reduce inflammation relevant to IBD. If development succeeds, it could point to new, microbiome-based therapeutic approaches for people with Crohn’s...

The project aims to enable simultaneous RNA-level profiling of microbes and host cells from human biopsies, which could reveal early microbial and host gene-expression patterns linked to subclinical Crohn’s disease and...

The study links a common plant compound (oxalate) to higher stool levels and worse inflammation in IBD, suggesting diet and gut handling of oxalate could affect disease activity and that microbiome-targeted strategies...

This study reports a new herbal hydrogel designed to repair the intestinal barrier, shift gut microbes, and modulate immune signals (IL-22/IL-34) in preclinical models of ulcerative colitis—ideas that could inform future...

Adding a mesalazine retention enema to oral mesalazine improved short-term symptom relief and endoscopic signs of mucosal healing in mild-to-moderate left-sided ulcerative colitis in this retrospective study. That could...

CT-detected terminal ileitis was due to Crohn’s disease in only a small minority (12.5%) of cases in this cohort, so most patients with this imaging finding will need further testing to determine the cause.

Blood biomarkers that predict vedolizumab response could help patients and clinicians choose the most effective therapy sooner and avoid ineffective treatments. The study suggests LRG and MCP‑1 may differentiate...

If you have moderate–severe ulcerative colitis, this study suggests that typical phase III trials may exclude more than half of patients seen in specialty clinics, which can make trial results less representative of...

The paper identifies a potential microbiome–metabolite–PKC pathway by which an herbal formula reduced colonic injury in a rat model of UC; this could point to new targets for research into mucosal repair and...