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Articles focused on children and teens with Crohn's disease or IBD, including pediatric research, care, and family context.
Page 1 of 3 · 137 articles
A pediatric Phase 2 trial testing etrasimod could expand treatment options for children with moderately to severely active ulcerative colitis if later shown safe and effective. Families of affected children and their...
Growth and nutrition are common concerns in children with IBD because poor weight gain and short stature can affect long‑term health and development.
Cure8 found this source from Journal of paediatrics and child health, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Upadacitinib. Open the original...
IBD-U means no clear Crohn’s or ulcerative colitis diagnosis yet — that uncertainty can affect treatment decisions and follow-up. The review highlights tests that may help clarify diagnosis and stresses that many...
People with pediatric IBD-like intestinal inflammation, or caregivers, may encounter overlapping autoimmune conditions such as large-vessel vasculitis; recognizing that intestinal biopsy can be nondiagnostic is...
Early-onset IBD affects children worldwide and the commentary highlights that although deaths are declining, more children are living with IBD and social inequalities are widening — issues that can affect access to care,...
This study suggests that using 5‑ASA drugs early in children with Crohn’s disease was common but linked to more steroid use, delayed biologic treatment, and lower biologic durability — outcomes that matter for long‑term...
The study links changes in gut microbes and microbial functions with disease activity in children with IBD, suggesting the microbiome may play a role in recovery and could be a target to help sustain remission.
Perianal fistulas are a common and morbid complication of Crohn's disease in children; a reliable, less burdensome imaging tool could help assess severity and monitor response to therapy more often than MRI.
Capsule endoscopy can safely help diagnose small-bowel disease in very young children, including cases of suspected IBD, and may be particularly helpful when blood tests or imaging suggest inflammation or low albumin....
Parents and clinicians may wonder whether stressful events in early life increase a child’s long-term IBD risk. This large prospective study found no evidence that the measured early maternal or family adverse events...
Children with IBD can develop idiopathic acute pancreatitis that is often mild but may recur; knowing this helps families and clinicians monitor and manage pancreatic symptoms during active disease and after surgery.
People with CGD commonly have liver involvement and some develop IBD-like intestinal disease; recognizing and monitoring these complications may affect care and outcomes.
The study tested whether early maternal or family adverse events increase later IBD risk and—using two large Scandinavian birth cohorts with registry follow-up—found no association. That may reassure families worried...
A local Pediatric IBD Day helps children, families and care teams connect, learn practical skills for daily life with IBD, and reduces the burden of travelling for specialized pediatric care. For families in...
Drug levels and how patients reach remission can differ depending on prior biologic use. For families and clinicians managing pediatric Crohn's, this can affect how infliximab dosing and monitoring are interpreted after...
Children with IBD often wait years for medicines to be approved after adult approvals; this review shows many ongoing paediatric trials for biologics and small molecules that could improve treatment options.
VTE is a serious, potentially preventable complication in children with newly diagnosed IBD. Identifying risk factors could help clinicians consider which pediatric patients might need closer monitoring or future...
A new pediatric Phase 3 trial of filgotinib could broaden approved treatment choices for children and teens with moderate-to-severe ulcerative colitis, especially for those who have not responded to or cannot tolerate...
Finding neutralising anti-IL-10 antibodies in a subset of children with IBD may help explain why some patients have more severe, treatment‑resistant disease and points to a potential biomarker for risk stratification.
Back-to-school planning can reduce emergencies and missed care for students with chronic conditions, including Crohn’s disease. Preparing plans, communicating with school or campus staff, and knowing where to get care...
This study aims to identify which clinical or biological factors predict treatment response and serious complications in children with newly diagnosed IBD — information that could help tailor care for pediatric patients...
Intestinal ultrasound is a noninvasive imaging option that can help detect and monitor bowel inflammation without radiation. A new local program could improve access to this tool for people with IBD, including children.
Predicting who will respond to anti-TNF drugs could help avoid ineffective treatments, reduce delays to effective therapy, and personalize care for children with Crohn's disease.
This pooled analysis focuses on children with IBD and reports that ustekinumab was associated with substantial clinical and steroid-free remission rates and a low incidence of serious adverse events—information that may...
If validated, metabolite patterns could help predict which children will reach remission on vedolizumab, potentially guiding treatment choices and avoiding ineffective therapy.
Mirikizumab is being tested specifically in children with moderate-to-severe Crohn’s disease; successful results could expand treatment options for pediatric IBD. The study measures both symptom-based and endoscopic...
This trial is testing whether continued mirikizumab treatment helps children and teens with ulcerative colitis or Crohn’s disease achieve and maintain remission over the long term. Results could expand pediatric...
A structured ERP adapted for children could shorten hospital stays and improve recovery after pediatric GI surgery; this trial tested both clinical effectiveness and real-world implementation across many pediatric...
An extra mRNA COVID-19 vaccine dose produced only modest increases in antibody and T‑cell responses in immunosuppressed children (including those with IBD), so vaccine protection may still be lower than in healthy...
If validated, a simple ultrasound-based score could reduce the need for invasive endoscopy to monitor disease activity in children with ulcerative colitis. Noninvasive monitoring is especially valuable in pediatrics.
Oral signs such as persistent lip swelling can be an early presentation of Crohn’s disease in adolescents and may prompt testing that leads to earlier diagnosis and treatment.
Patients on anti-TNF biologics often seek safe ways to support gut microbial health. This trial tests a prebiotic supplement (2'-FL) for safety and whether it increases beneficial bacteria and butyrate in young people...
Endoscopy comfort and sedation differ between pediatric and adult settings, and worse adult experiences could deter young adults from needed surveillance or care. Addressing sedation choice, communication, and provider...
Adolescents with IBD often experience abdominal pain that affects daily life. This study suggests psychological resilience — especially optimism and mindfulness — is linked with less pain, pointing to nonpharmacologic...
This paper suggests that epithelial barrier structure and function may be altered in very early onset pediatric IBD. That could help researchers study disease mechanisms and eventually guide targeted therapies for...
This study compares two commonly used anti‑TNF biologics in children with Crohn’s disease using real‑world prospective data, so its findings are directly relevant to treatment choice, expectations for 1‑year remission,...
UGI involvement in children with IBD was common and linked to a more severe disease course — lower remission rates and more frequent need for biologic therapy — which could affect monitoring and treatment planning.
Shorter height at IBD diagnosis was more common in Hispanic/Latino children and those without private insurance, which may reflect inequities in timely diagnosis and access to nutrition and care—issues that can affect...
A Phase 3 study is testing whether oral tofacitinib can induce and maintain remission in children with moderate-to-severe ulcerative colitis — a key step before pediatric regulatory approvals and wider clinical use.
This study provides region-specific pediatric IBD data from the Philippines, highlighting prevalence of very-early-onset disease, perianal involvement in Crohn's, and factors (diagnostic delay, wasting, pancolitis)...
Faster remission can reduce symptoms, school disruption, and steroid exposure for children with IBD. If earlier infliximab level checks reliably speed remission, clinicians could adjust dosing sooner to improve outcomes.
SpA is a frequent but underrecognized extraintestinal manifestation in people with IBD; validated screening tools can help identify patients who need rheumatology evaluation. Earlier detection may address joint symptoms...
The oral microbiome in children with Crohn's disease appears to reflect disease severity and changes with treatment, suggesting a potential noninvasive biomarker for monitoring response to nutritional therapies like CDED...
This large pediatric registry study suggests children starting infliximab biosimilars have similar 12‑month clinical outcomes and treatment durability as those starting the originator drug — reassuring for patients and...
This trial could provide long-term safety data on guselkumab for children with moderate-to-severe Crohn's disease or ulcerative colitis and offers continued access to the drug for participants from earlier pediatric...
The study explores engineering HSPCs to induce IL-10–mediated, antigen-specific regulatory responses, which could lead to new cell-based strategies for children with refractory IBD who do not respond to current...
Fatigue is a common, impactful symptom in pediatric and young-adult IBD but is poorly defined and measured, limiting the ability to design age-appropriate supports. This review highlights gaps that affect patients' daily...
