Fistula

Perianal fistulas are a serious, common complication of Crohn's disease that are often difficult to heal. This study tests a real-world combination of surgery plus an approved IL-23 inhibitor (mirikizumab) to see if...

Comparative real-world data may help patients and clinicians weigh expected benefits and risks of risankizumab versus ustekinumab in Crohn’s disease, including effects on steroid-free remission and fistula healing.

Population estimates help patients understand how common IBD is and show that ulcerative colitis is more common than Crohn’s in this survey. Knowing prevalence and who is more likely to be diagnosed can help people feel...

This Taiwanese multicenter real-world study reports high 52-week clinical response and remission rates, sustained one-year drug persistence, and meaningful fistula healing with ustekinumab in patients with Crohn’s...

The study points to a specific immune cell type (pro-inflammatory CD4+ macrophages) and altered cellular interactions in rectal tissue that are linked to perianal fistulizing Crohn's disease, which may help explain...

Someone with Crohn’s disease and limited remaining small intestine may face high-risk surgical choices. This case report suggests a specialized oral supplement used with conservative care was associated with fistula...

The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...

People with an ileal pouch after UC/IBDU often struggle with fecal incontinence and reduced quality of life. This trial is testing a noninvasive device (Emsella chair) aimed at improving incontinence and patient-reported...

Pouch-related fistula is a serious late complication after IPAA. The study suggests people with UC who undergo IPAA may have higher fistula risk than patients with FAP, and that inflammatory pouch disease (like...

AI models that combine CTE/MRE imaging with clinical and molecular data could improve objective classification of small-bowel Crohn's disease and help predict which patients are likely to respond to medical therapy...

Perianal fistulas in Crohn’s disease are hard to treat and preserving continence is important. Long-term data suggesting laser ablation can achieve sustained healing in some patients are relevant for treatment decisions.

The study maps cellular and molecular programs that drive transformation of fissures into fistulas in Crohn's disease, pointing to early remodeling processes and specific molecular pathways that could be targeted to...

The study indicates that active inflammation—measured by CDAI and PDAI—drives poorer quality of life in Crohn's disease more than the mere presence of fistulas. That shifts focus toward controlling inflammation to...

Perianal fistulizing Crohn's disease is difficult to treat and many patients have failed anti-TNF therapy. Evidence that ustekinumab achieves high clinical fistula response and remission rates in a real-world multicenter...

Perianal inflammatory lesions are common in Crohn's disease and may mark higher cancer-related risk; knowing their association with worse survival after anorectal cancer surgery can inform discussions about prognosis and...

Findings are relevant because they describe outcomes and predictors of conversion for a minimally invasive surgery option (SILS) that some patients with Crohn's disease may be offered. Understanding risk factors can help...

Perianal fistulas are a serious complication of Crohn’s disease with limited high-quality trial evidence. This randomized trial suggests ustekinumab may increase the chance of combined clinical and MRI remission at 12...

Perianal fistulizing Crohn's disease is a disabling complication; a subcutaneous form of infliximab could lower treatment burden and expand options if its effectiveness and safety in this specific setting are confirmed.

The article helps patients and caregivers recognize common symptoms and complications, understand causes and risk factors, and see why ongoing specialist care and lifestyle measures matter for long-term management.

Fibrosis and stricturing are key problems in Crohn’s disease with limited therapies; this study identifies a microbiota–bile acid–GPBAR1 pathway by which a specific probiotic mix reduced inflammation and fibrosis in...

People with IBD who also have bleeding disorders face special risks during endoscopy, surgery, and when using immunosuppressive drugs. This case shows that coordinated care and hemostatic support can allow diagnosis and...

Identifies features associated with the new international definition of difficult‑to‑treat Crohn’s disease and links DTT status to greater mental fatigue. Biomarker differences (IL‑5, IL‑10) may point to distinct immune...

The study suggests upadacitinib may improve both symptoms and MRI‑documented healing of perianal fistulas in Crohn’s disease, offering a potential treatment option especially for patients who have not previously received...

Small-bowel Crohn's disease often causes strictures and fistulas and typically needs more imaging and procedural care than colonic disease, so patients and clinicians should be aware of its distinct risks and treatment...

This story shows how untreated or undiagnosed Crohn’s symptoms — especially perianal disease and an abdominal abscess — can become life-threatening. It underscores the importance of seeking medical attention for...

This trial shows darvadstrocel did not outperform placebo for complex perianal Crohn’s fistulas, so it does not support changing care now. High healing rates after surgical curettage and closure suggest the surgical step...

The article outlines complications that can come from Crohn’s disease, many of which may need tests, medication, or surgery. Knowing these helps you recognize warning signs and talk with your care team about prevention...

This article reports an investigational stem cell therapy (StemSmart MSCs) showing safety and clinical responses in a small group of patients with fistulising Crohn’s disease — a serious complication that’s often hard to...

Some people with moderate-to-severe Crohn’s who don’t fully respond to one advanced therapy may hear about adding a second drug. This article explains when clinicians might consider that approach, the potential benefits...

Perianal fistulas are a significant complication of Crohn’s disease that can be hard to treat. A phase 3 trial reported that guselkumab improved combined fistula remission versus placebo, which could represent a new...

Cure8 could only read part of this source from rttnews.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Guselkumab, and IL-23 inhibitor.

The episode clarifies key differences between Crohn’s and ulcerative colitis, outlines common symptoms that should prompt medical evaluation, and reviews monitoring and complication risks that affect long‑term care.

Knowing the range of Crohn’s symptoms helps you recognize when to seek care, track disease patterns, and explain concerns to your clinician. The article highlights location-based differences and serious complications...

Women with Crohn’s may have additional or different symptoms (period changes, painful sex, fertility concerns, bone and iron problems) that can affect daily life and long-term health. Recognizing these issues helps guide...

Patients considering switching biologics or clinicians choosing a second‑line therapy may care because the study suggests ustekinumab had better long‑term persistence and improving remission rates compared with anti‑TNF...

Perianal fistulas are a serious, hard-to-treat complication of Crohn disease. Fast Track status may speed development of a new implantable stem cell therapy that aims to close fistulas and promote local healing. Ongoing...

Crohn’s can sometimes cause flare-ups or complications that make working difficult or impossible; disability benefits can replace part of lost income. The article lays out the types of benefits and what the SSA looks for...

Market reports highlight which companies and drug types are investing in Crohn's disease — that can signal upcoming therapies, trial activity, and availability. Mentions of trials (for example anti‑TL1A) may be of...

Vulvar Crohn’s is an uncommon but real extraintestinal manifestation that can cause painful skin changes and sometimes appears before GI Crohn’s is diagnosed. Knowing about it may speed diagnosis and lead to coordinated...

This article reports the start of a first-in-human trial testing extracellular vesicles as a new regenerative treatment for complex perianal fistulas in Crohn's disease, a hard-to-treat complication with limited options.

Knowing the type of Crohn’s disease helps explain where symptoms come from and what treatments or procedures might be considered. The article links specific symptoms and complications to each anatomical pattern of...

This article reassures people with Crohn’s that newer medications can control inflammation and lower complication and surgery risk. It also highlights the kinds of complications to watch for and ongoing research into...

Anal fistulas are a common and often painful complication of Crohn’s disease that usually need medical or surgical treatment. Managing the underlying Crohn’s with biologic therapy is often necessary for fistulas to heal....

Understanding the differences between Crohn’s and ulcerative colitis helps patients and caregivers recognize likely symptom patterns, know which tests and treatments are commonly used, and when to seek specialist care....

The article outlines complications of untreated Crohn’s that can become life threatening (sepsis, perforation, toxic megacolon, severe malnutrition, colorectal cancer). Knowing these risks helps people with Crohn’s...

Perianal fistulas are serious, hard-to-treat complications in pediatric Crohn disease. The study suggests starting anti-TNFα therapy early — especially for kids with perianal lesions — may lower the chance of developing...

The study suggests starting anti-TNF drugs early in children with Crohn's could strongly lower the chance of developing anal fistulas, a serious complication that often requires surgery. Preventing fistulas can reduce...

If your Crohn’s gets worse, your care plan may change — from new medicines to nutritional support or surgery — and this article summarizes common steps doctors take to prevent complications and control inflammation.