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Pediatrics and family

Children, teens, growth, school, parents, caregivers, and family-centered IBD updates.

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Risk factors for postoperative intra-abdominal abscess following minimally invasive ileocecal resection in children with Crohn's disease.
Surgical endoscopy

Risk factors for postoperative intra-abdominal abscess following minimally invasive ileocecal resection in children with Crohn's disease.

Postoperative intra-abdominal abscesses are a common, serious short-term complication after ileocecal surgery in children with Crohn’s disease and can lengthen hospital stay and delay restarting medical treatment.

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The prevalence and impacts of NUDT15 variants in pediatric-onset inflammatory bowel disease patients in Taiwan.
Pediatrics and neonatology

The prevalence and impacts of NUDT15 variants in pediatric-onset inflammatory bowel disease patients in Taiwan.

NUDT15 gene variants can strongly increase the risk of neutropenia from thiopurine drugs used in IBD. Knowing a child’s NUDT15 status could help prevent serious low white blood cell counts by guiding drug choice or...

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Very Early-Onset Ulcerative Colitis Manifesting as Acute Rectal Prolapse and Persistent Hematochezia in a Three-Year-Old Child: An Observational Analytic Case Study of Diagnostic Trajectory and Multimodal Intervention
Scientific Journal of Pediatrics

Very Early-Onset Ulcerative Colitis Manifesting as Acute Rectal Prolapse and Persistent Hematochezia in a Three-Year-Old Child: An Observational Analytic Case Study of Diagnostic Trajectory and Multimodal Intervention

This case highlights that full-thickness rectal prolapse in a toddler can be caused by very early-onset ulcerative colitis rather than isolated pediatric prolapse or allergy.

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Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.
Patient preference and adherence

Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.

Self-management is central to long-term IBD control. The study shows many patients have limited disease knowledge and less favorable attitudes, which could affect adherence, lifestyle choices, and follow-up.

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Noninvasive evaluation of liver fibrosis in newly diagnosed pediatric Crohn's disease: Elastography and fibrotic biomarkers at diagnosis.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University

Noninvasive evaluation of liver fibrosis in newly diagnosed pediatric Crohn's disease: Elastography and fibrotic biomarkers at diagnosis.

Parents and clinicians often worry about liver disease when children are diagnosed with Crohn's. This study suggests advanced liver fibrosis is uncommon at diagnosis, but elastography and fibrotic biomarkers can be...

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Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.
European journal of pediatrics

Paediatric Helicobacter pylori infection and allergic and inflammatory diseases: a contemporary systematic review with meta-analysis.

Families and clinicians often wonder whether H. pylori infection in childhood affects risks for asthma, IBD, celiac disease, or other immune-mediated disorders.

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Clinical characteristics of patients with overlapping eosinophilic esophagitis and inflammatory bowel disease in a national real-world cohort.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

Clinical characteristics of patients with overlapping eosinophilic esophagitis and inflammatory bowel disease in a national real-world cohort.

Overlap of EoE and IBD appears uncommon but more frequent than in the general population and is linked to more allergic disease and higher steroid exposure without clearer increases in esophageal scarring. That may...

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Fecal Microbiota Transfer for Recurrent Clostridioides difficile Infection: A Retrospective Single-Center Analysis.
Zeitschrift fur Gastroenterologie

Fecal Microbiota Transfer for Recurrent Clostridioides difficile Infection: A Retrospective Single-Center Analysis.

FMT is shown here to be an effective option for treating recurrent C. difficile infection, including for patients who also have IBD — a group often vulnerable to recurrent infections and complications.

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Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov

Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease

A Phase 3 study is testing whether upadacitinib is safe and effective for children with moderate-to-severe Crohn's disease who have not responded to or cannot take other therapies. Positive results could expand treatment...

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Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period
International Journal of Molecular Sciences

Changes in Serum MMP-9 and TIMP-1 Concentrations in Children with Inflammatory Bowel Disease over a Six-Month Observation Period

If reliable, blood biomarkers that track IBD activity could help noninvasively follow children with Crohn’s disease or ulcerative colitis. This study suggests MMP-9 and TIMP-1 change with disease course but did not show...

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Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.
Journal of pediatric gastroenterology and nutrition

Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study.

Predicting early need for infliximab could help identify children with Crohn’s disease who may benefit from earlier biologic therapy instead of prolonged conventional treatment. A reliable prediction tool may shorten...

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Prior Ustekinumab Exposure and Ulcerative Colitis Are Associated with Suboptimal Trough Levels in Patients Receiving Advanced-Line Vedolizumab or Ustekinumab for Inflammatory Bowel Disease: A Cross-Sectional Cohort Study
Biomedicines

Prior Ustekinumab Exposure and Ulcerative Colitis Are Associated with Suboptimal Trough Levels in Patients Receiving Advanced-Line Vedolizumab or Ustekinumab for Inflammatory Bowel Disease: A Cross-Sectional Cohort Study

Patients on biologic therapy often have drug levels and antidrug antibodies measured to guide care. This study suggests prior biologic history, disease type (UC vs CD) and which biologic is currently used may affect...

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Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.
Scandinavian journal of gastroenterology

Time trends in patients with ulcerative colitis and crohn's disease not receiving IBD-specific pharmacological treatment within one and three years of diagnosis - a nationwide cohort study.

A sizable minority of people newly diagnosed with IBD—about 1 in 5 with Crohn’s and 1 in 10 with ulcerative colitis—received no IBD-specific drugs within the first year. Understanding who is untreated and why could...

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Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study
Frontiers in pediatrics

Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Infliximab, and Anti-TNF. The original article is from Frontiers in pediatrics.

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Prevalence of Enteric Hyperoxaluria in Crohn's Disease, Cystic Fibrosis, and After Bariatric Surgery: A Systematic Review
Europe PMC

Prevalence of Enteric Hyperoxaluria in Crohn's Disease, Cystic Fibrosis, and After Bariatric Surgery: A Systematic Review

Enteric hyperoxaluria increases risk of calcium oxalate kidney stones and kidney injury. Knowing how common EH is in Crohn's disease and after bariatric surgery helps identify who might benefit from screening and...

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Elective combined surgical management of concurrent gastrocolic and duodenocolic fistulae in longstanding Crohn's disease.
Clinical journal of gastroenterology

Elective combined surgical management of concurrent gastrocolic and duodenocolic fistulae in longstanding Crohn's disease.

Internal fistulae can be clinically silent yet serious in long-standing Crohn's disease. Early cross-sectional imaging detected rare gastrocolic and duodenocolic fistulae in this patient, and elective combined surgery...

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Switching From Originator to Biosimilar Infliximab in Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis
JCC Plus

Switching From Originator to Biosimilar Infliximab in Pediatric Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis

This review directly addresses whether switching from originator infliximab to a biosimilar affects disease control or safety in children with IBD — a common practical concern for families and clinicians. Its pooled data...

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Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review
Inflammatory Bowel Diseases

Current evidence for first-line advanced therapies in pediatric ulcerative colitis: a critical review

Families and clinicians deciding on a first biologic for a child with ulcerative colitis need to know which drugs have pediatric-specific evidence. This review shows infliximab has the strongest pediatric data, while...

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Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.
The New Zealand medical journal

Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.

This study reports real-world short-term outcomes after colectomy for IBD at a tertiary New Zealand centre, including complication rates and how often restorative surgery (ileal pouch) was later performed—information...

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Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.
Gut

Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.

Identifying people at very early, preclinical stages of Crohn’s disease could allow enrollment in prevention trials and earlier intervention. Faecal calprotectin may help select higher‑risk first‑degree relatives for...

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Psychological Functioning and Parent-Child Mental Health Interrelations in Pediatric Gastrointestinal Autoimmune Disorders.
Clinical child psychology and psychiatry

Psychological Functioning and Parent-Child Mental Health Interrelations in Pediatric Gastrointestinal Autoimmune Disorders.

Emotional functioning and parent-child mental health are linked with anxiety, depression, and quality of life in children with IBD and other GI autoimmune disorders. Identifying these issues may help families get...

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