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Pediatrics and family

Children, teens, growth, school, parents, caregivers, and family-centered IBD updates.

Page 1 of 5 · 212 articles

A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis
ClinicalTrials.gov

A Study of How the Medicine Called "Etrasimod" Works in Children With the Gut Disease Called Ulcerative Colitis

A pediatric Phase 2 trial testing etrasimod could expand treatment options for children with moderately to severely active ulcerative colitis if later shown safe and effective. Families of affected children and their...

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Efficacy and Safety of Upadacitinib in Refractory Very-Early-Onset Ulcerative Colitis: A Case Report.
Journal of paediatrics and child health

Efficacy and Safety of Upadacitinib in Refractory Very-Early-Onset Ulcerative Colitis: A Case Report.

Cure8 found this source from Journal of paediatrics and child health, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Upadacitinib. Open the original...

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Takayasu Arteritis in a Child with Chronic Active Proctitis of Unspecified Etiology: A Case Report with Diagnostic Challenges and Literature Review.
Journal of visualized experiments : JoVE

Takayasu Arteritis in a Child with Chronic Active Proctitis of Unspecified Etiology: A Case Report with Diagnostic Challenges and Literature Review.

People with pediatric IBD-like intestinal inflammation, or caregivers, may encounter overlapping autoimmune conditions such as large-vessel vasculitis; recognizing that intestinal biopsy can be nondiagnostic is...

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Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease.

This study suggests that using 5‑ASA drugs early in children with Crohn’s disease was common but linked to more steroid use, delayed biologic treatment, and lower biologic durability — outcomes that matter for long‑term...

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Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease.
World journal of clinical pediatrics

Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease.

The study links changes in gut microbes and microbial functions with disease activity in children with IBD, suggesting the microbiome may play a role in recovery and could be a target to help sustain remission.

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Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease.

Perianal fistulas are a common and morbid complication of Crohn's disease in children; a reliable, less burdensome imaging tool could help assess severity and monitor response to therapy more often than MRI.

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Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis
PLOS One

Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis

The study links worse UC activity with higher rates of anxiety and depression and with poorer quality of life among patients in Pakistan, suggesting mental-health screening could be relevant to overall disease...

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Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study
Journal of Pediatric Gastroenterology and Nutrition

Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study

Parents and clinicians may wonder whether stressful events in early life increase a child’s long-term IBD risk. This large prospective study found no evidence that the measured early maternal or family adverse events...

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Idiopathic Acute Pancreatitis in Paediatric Inflammatory Bowel Disease: Clinical Features and Outcomes in a Retrospective Single-Centre Study.
Journal of paediatrics and child health

Idiopathic Acute Pancreatitis in Paediatric Inflammatory Bowel Disease: Clinical Features and Outcomes in a Retrospective Single-Centre Study.

Children with IBD can develop idiopathic acute pancreatitis that is often mild but may recur; knowing this helps families and clinicians monitor and manage pancreatic symptoms during active disease and after surgery.

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Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints.
The American surgeon

Colorectal Inflammatory Bowel Disease in Sub-Saharan Africa: Diagnostic Challenges and Systemic Care Constraints.

The review highlights that colorectal IBD is under-recognized and often mistaken for infectious colitis in sub‑Saharan Africa due to limited diagnostic and specialist resources, which can delay appropriate care.

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Self-Care and Illness Perception in Inflammatory Bowel Disease: Identifying Adaptive and Maladaptive Profiles Through Person-Centered Analysis
Psychiatric Quarterly

Self-Care and Illness Perception in Inflammatory Bowel Disease: Identifying Adaptive and Maladaptive Profiles Through Person-Centered Analysis

This study shows that people with IBD can display distinct self-care and illness-perception profiles rather than a single pattern; tailoring education and psychological support to these profiles could improve...

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Uveitis and Scleritis as Early Signals of Undiagnosed IBD: A Tiered Screening Framework to Reduce Diagnostic Delay.
Ocular immunology and inflammation

Uveitis and Scleritis as Early Signals of Undiagnosed IBD: A Tiered Screening Framework to Reduce Diagnostic Delay.

Recognizing eye inflammation as a possible early sign of IBD could shorten diagnostic delays and lead to earlier gastroenterology evaluation and treatment, which is especially important for children who often wait years...

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C-Reactive Protein-to-Albumin Ratio in Pediatric Inflammatory Bowel Disease: Associations with Disease Activity and Comparison with C-Reactive Protein Alone
Diagnostics

C-Reactive Protein-to-Albumin Ratio in Pediatric Inflammatory Bowel Disease: Associations with Disease Activity and Comparison with C-Reactive Protein Alone

This paper evaluates CAR, a simple blood‑based biomarker, in children with IBD and finds it reflects disease severity and changes over time in pediatric Crohn’s disease. That matters because reliable, easy-to-measure...

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Incidence and Risk Factors for Persistent Perineal Sinus After Proctectomy in Crohn Disease: A Single-center Retrospective Cohort Study.
Annals of surgery

Incidence and Risk Factors for Persistent Perineal Sinus After Proctectomy in Crohn Disease: A Single-center Retrospective Cohort Study.

Persistent perineal sinus is a common and impactful complication after proctectomy for Crohn disease that can prolong recovery and require further care. Knowing rates of healing and risk factors can help patients and...

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Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries.
Paediatric drugs

Novel Agents on the Therapeutic Horizon For Paediatric Inflammatory Bowel Diseases: An Analysis of Clinical Trials Registries.

Children with IBD often wait years for medicines to be approved after adult approvals; this review shows many ongoing paediatric trials for biologics and small molecules that could improve treatment options.

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Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study
Saudi Journal of Gastroenterology

Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study

Stigma and social support appear to meaningfully relate to quality of life for adults with IBD in Saudi Arabia. Understanding which coping strategies and support sources help could inform patient education and support...

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A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis
ClinicalTrials.gov

A Study Evaluating the Effects of Filgotinib in Children and Teenagers With Ulcerative Colitis

A new pediatric Phase 3 trial of filgotinib could broaden approved treatment choices for children and teens with moderate-to-severe ulcerative colitis, especially for those who have not responded to or cannot tolerate...

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Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.
Gut

Neutralising autoantibodies against IL-10 and HLA-DRB1*01:03 in paediatric patients with inflammatory bowel disease.

Finding neutralising anti-IL-10 antibodies in a subset of children with IBD may help explain why some patients have more severe, treatment‑resistant disease and points to a potential biomarker for risk stratification.

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Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey.

Patients with short bowel syndrome and their caregivers can face heavy, multidimensional burdens including dependence on parenteral nutrition/IV hydration, frequent symptoms like fatigue, increased healthcare use, and...

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Multi-modal ensemble learning prediction of anti-TNF treatment response in pediatric patients with Crohn's disease using clinical, radiomic, and deep learning MR enterography features.
Inflammatory bowel diseases

Multi-modal ensemble learning prediction of anti-TNF treatment response in pediatric patients with Crohn's disease using clinical, radiomic, and deep learning MR enterography features.

Predicting who will respond to anti-TNF drugs could help avoid ineffective treatments, reduce delays to effective therapy, and personalize care for children with Crohn's disease.

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Metabolomics predict treatment response to vedolizumab in pediatric IBD: results from the prospective VedoKids cohort study.
Inflammatory bowel diseases

Metabolomics predict treatment response to vedolizumab in pediatric IBD: results from the prospective VedoKids cohort study.

If validated, metabolite patterns could help predict which children will reach remission on vedolizumab, potentially guiding treatment choices and avoiding ineffective therapy.

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A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)
ClinicalTrials.gov

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

This trial is testing whether continued mirikizumab treatment helps children and teens with ulcerative colitis or Crohn’s disease achieve and maintain remission over the long term. Results could expand pediatric...

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Immunogenicity of an additional COVID-19 mRNA vaccine dose in immunosuppressed children with two doses of primary immunization.
Pediatrics and neonatology

Immunogenicity of an additional COVID-19 mRNA vaccine dose in immunosuppressed children with two doses of primary immunization.

An extra mRNA COVID-19 vaccine dose produced only modest increases in antibody and T‑cell responses in immunosuppressed children (including those with IBD), so vaccine protection may still be lower than in healthy...

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The Milan Ultrasound Criteria (MUC) in Pediatric Ulcerative Colitis: A Pilot Study of the Correlation With Clinical, Endoscopic and Ultrasound Activity Scores
JCC Plus

The Milan Ultrasound Criteria (MUC) in Pediatric Ulcerative Colitis: A Pilot Study of the Correlation With Clinical, Endoscopic and Ultrasound Activity Scores

If validated, a simple ultrasound-based score could reduce the need for invasive endoscopy to monitor disease activity in children with ulcerative colitis. Noninvasive monitoring is especially valuable in pediatrics.

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