Mental health and quality-of-life topics

Depression

Depression articles covering mental health, quality of life, coping, support, and daily functioning for people affected by IBD. Quality-of-life context emphasizes daily functioning, mental health, fatigue, and support.

31 articles

Understanding the Impact of Perceived Stigma on Healthcare Perception and Medication Utilization Among Black Individuals with Inflammatory Bowel Diseases
Digestive Diseases and Sciences

Understanding the Impact of Perceived Stigma on Healthcare Perception and Medication Utilization Among Black Individuals with Inflammatory Bowel Diseases

Perceived stigma may affect how Black people with IBD view their care and whether they stick with medications, which can influence disease management and outcomes. Understanding these links can point to targets for...

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Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression
Journal of Nanobiotechnology

Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression

The study presents a novel probiotic-based delivery system that targets both intestinal inflammation and anxiety/depression through the gut–brain axis, a potentially relevant concept for people with IBD who commonly...

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Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis
PLOS One

Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis

The study links worse UC activity with higher rates of anxiety and depression and with poorer quality of life among patients in Pakistan, suggesting mental-health screening could be relevant to overall disease...

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A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
ClinicalTrials.gov

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

The trial could show whether a smart-label app plus clinician alerts improves medication adherence and downstream clinical outcomes for people with Crohn's disease or ulcerative colitis starting oral or subcutaneous...

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Efficacy of psychotherapies in individuals with inflammatory bowel disease: A systematic review and meta-analysis
World Journal of Psychiatry

Efficacy of psychotherapies in individuals with inflammatory bowel disease: A systematic review and meta-analysis

The review shows psychotherapies can improve quality of life and reduce anxiety and depression in people with IBD, outcomes that matter for daily functioning even when intestinal symptoms may not change.

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Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn’s disease
Journal of Gastroenterology

Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn’s disease

This study suggests brain glymphatic function — a fluid-clearance system — may be altered in people with Crohn’s disease and could relate to inflammation and common neuropsychiatric symptoms like fatigue, anxiety,...

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Short-term psychiatric outcomes after ostomy vs nonostomy surgery in biologic-treated IBD patients.
Inflammatory bowel diseases

Short-term psychiatric outcomes after ostomy vs nonostomy surgery in biologic-treated IBD patients.

Short-term mental health problems (depression, anxiety, adjustment disorders) appear more common after ostomy creation than after nonostomy IBD surgery among biologic-treated adults. Awareness may help patients and...

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Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews
JCC Plus

Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews

Depressive disorders—diagnosed using structured clinical interviews—appear to be relatively common in people with IBD, which has implications for screening and referral to mental health care within IBD clinics.

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Research hotspots, context, and future directions of ulcerative colitis comorbid with depression from 2006 to 2025: a bibliometric and visualization analysis
Frontiers in Medicine

Research hotspots, context, and future directions of ulcerative colitis comorbid with depression from 2006 to 2025: a bibliometric and visualization analysis

Depression is common in people with ulcerative colitis and affects quality of life and disease outcomes. Knowing research trends helps patients and clinicians see where evidence and care approaches are focused,...

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Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations
Microorganisms

Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations

This study suggests erythritol — a common non-nutritive sweetener — may worsen experimental colitis and depression-like behavior in mice via microbiome and metabolic changes, raising questions about how ultra-processed...

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Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk.
Depression and anxiety

Comorbidity Between Mood Disorders and Chronic Somatic Diseases, With a Focus on Cardiometabolic Disease, and Its Mechanistic Crosstalk.

Mood disorders commonly co-occur with chronic somatic diseases, including IBD; understanding shared mechanisms may explain worse outcomes and suggest multidisciplinary care needs.

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Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.
Journal of psychosomatic research

Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.

Sexual dysfunction is common in IBD and—according to this study—appears more strongly linked to psychological and demographic factors than to disease activity or muscle loss. Recognizing and treating mental-health issues...

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Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial
Digestive Diseases and Sciences

Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial

Self‑management programs delivered by nurses may help people with IBD improve daily functioning, confidence in managing their condition, and quality of life even when inflammation markers don’t change. That matters...

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Inflammatory Bowel Disease and Its Unique Impact on Body Image: A Qualitative Exploration.
Journal of clinical psychology

Inflammatory Bowel Disease and Its Unique Impact on Body Image: A Qualitative Exploration.

Body-image concerns in IBD are linked with poorer mental health, eating behaviours, and overall quality of life. Understanding these experiences can help clinicians and support services better address emotional and...

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Exploring bidirectional causal relationships between ulcerative colitis and depression via the gut-brain axis: A Mendelian randomization study with plasma protein mediator analysis.
Journal of affective disorders

Exploring bidirectional causal relationships between ulcerative colitis and depression via the gut-brain axis: A Mendelian randomization study with plasma protein mediator analysis.

People with ulcerative colitis commonly experience depression; understanding whether the relationship is causal and which blood proteins might mediate it could help researchers develop biomarkers or new therapies...

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Microbiome-driven alterations in tryptophan metabolism contribute to behavioral comorbidities in the Muc2 knockout mouse model of chronic colitis.

IBD is increasingly linked with anxiety, depression, and cognitive symptoms; this study suggests gut microbes may change tryptophan metabolism in colitis and contribute to those brain-related symptoms, which could point...

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