Research topics
Microbiome articles covering gut bacteria, microbial changes, microbiota research, and IBD disease mechanisms.
Page 1 of 6 · 283 articles
The study suggests a natural seaweed-derived polysaccharide could modify gut bacteria and immune signaling in ways that reduced experimental colitis, which may interest people looking for microbiota-targeted dietary...
This method helps translate complex paired microbiome and metabolome data into coherent functional modules; that could clarify microbial metabolic alterations in IBD or IBS and guide future biomarker or mechanistic...
The study suggests a dietary/prebiotic compound (2'-FL) can change gut microbes and patient-reported disease control in mild-to-moderate UC, which could point to non-drug ways to support symptoms and microbiome health.
The study links a polyphenol-rich diet to a specific microbiome change and a microbial metabolite (4-HPAA) that reduced inflammation in mouse models — offering a possible mechanism by which diet could influence Crohn's...
This study describes a new oral peptide hydrogel that, in mouse models, appears to reduce colitis severity by acting on both immune signaling (TLR4) and the gut microbiome. For people with UC, treatments that target both...
If validated, an imaging-derived adipose heterogeneity biomarker could help predict who will lose response to infliximab after induction, potentially guiding earlier treatment decisions and personalized monitoring for...
Treg/Th17 balance is a central immune mechanism implicated in IBD pathogenesis; understanding how microbes, metabolites, and tissue context control that balance could inform new biomarkers and targeted therapies.
Colon-targeted delivery systems aim to concentrate drugs in the colon, which could improve effectiveness and reduce systemic side effects for IBD and colorectal cancer treatments. Understanding these approaches helps...
This review summarizes human evidence that pesticides in the diet could affect the gut microbiome and may be linked to gastrointestinal outcomes including IBD; strongest consistent signals were for organochlorine...
The study identifies a gut bacterial metabolite that appears to reduce intestinal inflammation through SIRT1 stabilization and macrophage metabolic reprogramming — a potential new biological pathway relevant to Crohn’s...
Researchers are exploring a gut microbe–derived lipid (SoL A) that may reduce inflammation relevant to IBD. If development succeeds, it could point to new, microbiome-based therapeutic approaches for people with Crohn’s...
The study links a common plant compound (oxalate) to higher stool levels and worse inflammation in IBD, suggesting diet and gut handling of oxalate could affect disease activity and that microbiome-targeted strategies...
This study reports a new herbal hydrogel designed to repair the intestinal barrier, shift gut microbes, and modulate immune signals (IL-22/IL-34) in preclinical models of ulcerative colitis—ideas that could inform future...
The paper identifies a potential microbiome–metabolite–PKC pathway by which an herbal formula reduced colonic injury in a rat model of UC; this could point to new targets for research into mucosal repair and...
People with IBD may be interested because the review summarizes biological pathways that could link gut inflammation to brain changes seen in Alzheimer’s disease, suggesting possible shared mechanisms and future research...
People with ulcerative colitis may be interested because the study describes a natural compound that reduced inflammation and disease signs in a mouse model and acted through the gut microbiota and immune pathways —...
The study links NAD+ precursor (NMN) supplementation to changes in TGF-β–associated gene programs, intestinal immune signatures, and the gut microbiome in mouse colitis models — pathways relevant to fibrosis and...
People with UC often look for dietary supplements or ‘‘natural’’ add-ons. This review explains which nutraceutical approaches have the most and least clinical support, helping patients and clinicians weigh potential...
The study describes a mechanism by which Huaier granules reduced colitis-related inflammation in mice and cell models by targeting macrophage cGAS–STING signaling and altering the gut microbiome—information that could...
Prebiotics change how gut microbes ferment carbohydrates and produce metabolites that can affect gut health. For people with IBD, a prebiotic that is well fermented by their microbiota, increases beneficial bacteria and...
The work highlights a dietary polysaccharide that reduced inflammation and improved mucosal barrier function in a mouse colitis model through gut-microbiota changes — a mechanism relevant to IBD research and potential...
Early-onset IBD affects children worldwide and the commentary highlights that although deaths are declining, more children are living with IBD and social inequalities are widening — issues that can affect access to care,...
The study presents a novel nanomaterial approach that aims to protect both inflamed intestines and kidneys by restoring intestinal barrier function and microbiome balance—mechanisms relevant to IBD-related systemic...
The study links changes in gut microbes and microbial functions with disease activity in children with IBD, suggesting the microbiome may play a role in recovery and could be a target to help sustain remission.
The paper identifies a gut microbiome–driven pathway (flagellin → TLR5 → IL-15 → ARA) that might link intestinal microbial changes to systemic inflammation seen in long COVID and other immune-mediated diseases,...
The article reviews current and emerging IBD treatments and the biological reasons they may work — useful for patients wanting to understand treatment options and future directions. It highlights therapies beyond...
Dietary components and processed vegetarian/vegan products may alter the gut microbiome and intestinal barrier — both are relevant to IBD. This study will directly compare common vegan products and meat substitutes with...
This study describes a novel nanoparticle "nanomachine" approach aimed at fixing gut microbial and barrier dysfunction in IBD models and, by doing so, reducing secondary kidney injury—an intersection (gut–kidney axis)...
The study proposes new biomarker candidates (C5AR1, KDM2A, HCAR3) and microbiota-derived metabolites that might interact with those targets. If validated, that could guide future diagnostic tests or microbiome-targeted...
Researchers are testing whether baseline fecal microbiome profiles can predict who with mild ulcerative colitis will benefit from a specific prebiotic supplement. If validated, this approach could move dietary therapy...
The study suggests acetate (sodium acetate) can protect intestinal cells and reshape the gut microbiota in preclinical models of ulcerative colitis, pointing to a potential microbiome-linked therapeutic avenue that might...
This study suggests an environmental fungicide can disrupt gut microbes and reduce beneficial microbial tryptophan metabolites, promoting colitis in mice; dietary tryptophan reversed those effects in the model.
Microbiota-targeting treatments are an active area of IBD research, and biomaterials may help overcome delivery challenges that limit current microbiome therapies. Advances here could improve how well these approaches...
The studies identify a metabolic reason why the inflamed gut struggles to heal: inflammation reduces an enzyme (QPRT) needed for NAD+ production, starving regenerating intestinal cells of energy. That suggests...
The study introduces a phylogeny-aware AI method that may improve detection and interpretation of microbiome signatures linked to IBD and colorectal cancer, which could help research into microbial biomarkers relevant to...
The review outlines new research tools for investigating whether mycobacteria contribute to Crohn’s disease and how the microbiome might influence infection and intestinal inflammation, which could eventually inform...
If validated, blood protein signatures that appear years before symptoms could help identify people at higher risk of Crohn’s disease and point to lifestyle or dietary measures that alter early biology.
The study suggests a specific microbial metabolite, 3‑HPA, can link cold exposure to worse colitis by changing the microbiome and harming epithelial cell mitochondria and barrier function — a possible new mechanistic...
Timing of therapies and daily behaviors may affect drug metabolism, immune activity, and symptom patterns in IBD. Considering when treatments are given could potentially improve response, reduce toxicity, and help...
The study describes a new ultrasound-activated nanozyme that reduced intestinal inflammation and promoted mucosal repair in preclinical IBD models by scavenging ROS and modulating the gut microbiota—an approach that...
This trial tests whether the common sweetener sucralose alters the gut microbiome in people with Crohn’s disease in remission compared with healthy volunteers.
Dietary patterns like the Mediterranean diet may reduce inflammation and improve quality of life for people with Crohn’s disease by beneficially altering the gut microbiome and inflammatory markers. That could offer a...
The study suggests a targeted microbiome-based drug (sialidase inhibitor) may protect the mucus barrier and improve symptoms in ulcerative colitis without the broad disruption caused by antibiotics, which could be...
The review explains why many patients still fail current therapies and summarizes promising new research directions (microRNA, microbiome therapies, stromal cell approaches) that could change treatment strategies.
People with ulcerative colitis face a higher colorectal cancer risk driven in part by chronic inflammation; this review explains the molecular and immune mechanisms behind that risk and highlights biomarkers and...
The review connects animal-model discoveries (IL-23/IL-17 and TNF pathways, gut–joint interactions) to therapies and research priorities relevant to people with SpA and IBD-associated arthritis.
The study uses generative AI and microbiome/RNA data to search for biomarkers of intestinal fibrosis in Crohn’s disease, which could help spot scarring earlier and potentially prevent worsening complications like...
The paper reports a materials-based strategy to improve zinc delivery and bioavailability that reduced dose while preserving beneficial effects in a mouse colitis model—relevant because zinc supports intestinal health...
