Condition

Irritable bowel syndrome

IBS news when it appears alongside Crohn's disease, IBD, symptom overlap, diagnosis, or patient-facing digestive health updates.

Page 1 of 2 · 64 articles

Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
ClinicalTrials.gov

Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)

The study aims to clarify differences in visceral sensitivity and collect multiple biological samples that could help explain why some people with IBD have IBS-like symptoms. Findings could inform better symptom-targeted...

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Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.
Frontiers in cellular neuroscience

Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.

This review connects enteric sensory neuron dysfunction to symptoms common in IBS and IBD (pain, diarrhea, constipation, dysmotility). Understanding IPAN plasticity could point to new treatment targets that act locally...

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Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.
Autoimmunity reviews

Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.

If endometriosis is linked to other immune, allergic, or chronic pain conditions, people with endometriosis may benefit from broader evaluation and coordinated care beyond gynecology. The review suggests shared...

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Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention
International Journal of Molecular Sciences

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

The study suggests psychological (emotional) stress can worsen colitis-like inflammation via GSK3β-mediated neuroimmune changes, and that a probiotic (VSL#3) reduced many adverse effects in mice — relevant to...

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Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease
Frontiers in gastroenterology (Lausanne, Switzerland)

Irritable bowel syndrome-like symptoms are associated with increased healthcare utilization in patients with inflammatory bowel disease

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Irritable bowel syndrome, and Symptoms and flares. The original article is from Frontiers in...

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S100B in brain-gut-liver crosstalk: from glial activation to multiorgan inflammation.
Frontiers in immunology

S100B in brain-gut-liver crosstalk: from glial activation to multiorgan inflammation.

The review proposes S100B as a molecular link connecting enteric glial activation, intestinal barrier dysfunction, and liver/brain inflammation. If confirmed, this could help explain symptom overlap between gut and...

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Differential Enteric Glial and Mast Cell Characteristics Distinguish Microscopic Colitis Subtypes Relative to Healthy and Disease Controls, with Treatment-Associated Reductions in Glial Reactivity and Mast Cell Degranulation in Collagenous Colitis
Cells

Differential Enteric Glial and Mast Cell Characteristics Distinguish Microscopic Colitis Subtypes Relative to Healthy and Disease Controls, with Treatment-Associated Reductions in Glial Reactivity and Mast Cell Degranulation in Collagenous Colitis

The paper identifies subtype-specific changes in enteric glial cells and mast cell activity in microscopic colitis and shows some treatment-associated reductions after budesonide; that helps explain disease biology and...

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B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun
vancouversun.com

B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun

A dedicated Digestive Health Centre could make it easier for people with IBD (including children and teens) to access coordinated care—fewer separate visits and more centralized specialist services in one location.

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Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.
Medicine

Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.

People with Sjögren syndrome or clinicians caring for them may be interested because genetic data suggest Sjögren syndrome could modestly raise gastric ulcer risk and — unexpectedly — associate with lower IBS risk, while...

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Managing IBS-Like Symptoms in Quiescent Inflammatory Bowel Disease: A Meta-Analysis of Randomized Trials.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Managing IBS-Like Symptoms in Quiescent Inflammatory Bowel Disease: A Meta-Analysis of Randomized Trials.

People with IBD in remission commonly continue to have IBS-like symptoms; this review summarizes randomized trial evidence for symptom-directed treatments and finds no definitive best option.

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Bidirectional Brain-Gut Signaling in the Persistence of IBS-like Symptoms in Inflammatory Bowel Disease
NIH RePORTER

Bidirectional Brain-Gut Signaling in the Persistence of IBS-like Symptoms in Inflammatory Bowel Disease

Many people with IBD have ongoing IBS-like symptoms despite little or no intestinal inflammation. This project targets brain–gut and autonomic mechanisms that might explain symptom persistence and tests a non-drug...

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Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study
BMC Gastroenterology

Altered colonic keratin expression as a biomarker signature distinguishes IBD, microscopic colitis, and IBS – a retrospective study

Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.

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Serum osmolality as a potential marker of inflammatory bowel disease in patients with anxiety: a cross-sectional analysis based on the MIMIC-IV database
BMC Psychiatry

Serum osmolality as a potential marker of inflammatory bowel disease in patients with anxiety: a cross-sectional analysis based on the MIMIC-IV database

If validated, serum osmolality — a routine, low-cost blood measure — could become an additional marker to help identify IBD in certain hospitalized patients with anxiety. This could aid research and possibly improve...

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Leveraging electronic health records for subtype-dependent directionality in depression and gastrointestinal disease: a retrospective cohort study.
Journal of psychosomatic research

Leveraging electronic health records for subtype-dependent directionality in depression and gastrointestinal disease: a retrospective cohort study.

Depression and GI diseases often co-occur; knowing which tends to appear first — and that this varies by subtype — can help clinicians prioritize screening and integrated care.

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Global research trends in enteric nervous system and gut microbiota: a bibliometric analysis (2005-2025).
Frontiers in cellular and infection microbiology

Global research trends in enteric nervous system and gut microbiota: a bibliometric analysis (2005-2025).

The ENS–gut microbiota field intersects with IBD research through shared mechanisms (neuroinflammation, neuro‑immune interactions) and potential microbiota‑based therapies, so mapping trends helps patients and clinicians...

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Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention
World Journal of Gastroenterology

Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention

Piezo channels appear central to how mechanical signals influence the gut barrier, immunity, and secretion — processes that can affect inflammation and symptoms in IBD, IBS, and colon cancer. Understanding them could...

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Dynamic precision therapy in chronic gastrointestinal diseases: A focus on gastroesophageal reflux disease and inflammatory bowel disease-A narrative review and conceptual perspective.
Therapeutic advances in gastroenterology

Dynamic precision therapy in chronic gastrointestinal diseases: A focus on gastroesophageal reflux disease and inflammatory bowel disease-A narrative review and conceptual perspective.

The review lays out a multidimensional precision-care model that could help make IBD treatment more personalized, reduce unnecessary continuous medication, and use biomarker and technology-driven adjustments to manage...

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Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
ClinicalTrials.gov

Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction

Researchers are exploring ways to prioritize who needs colonoscopy sooner; adding TCM features to prediction models might change triage performance. Patients and clinicians interested in pre-endoscopic risk tools or...

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MAAMOUL: metabolic network-based discovery of microbiome-metabolome shifts in disease.
Bioinformatics (Oxford, England)

MAAMOUL: metabolic network-based discovery of microbiome-metabolome shifts in disease.

This method helps translate complex paired microbiome and metabolome data into coherent functional modules; that could clarify microbial metabolic alterations in IBD or IBS and guide future biomarker or mechanistic...

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Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function
Diseases

Vitamin D and Intestinal Diseases: Impact on Intestinal Immunity and Gut Barrier Function

Vitamin D appears linked to immune regulation, gut barrier health, and the microbiome—processes relevant to IBD and other intestinal disorders. Understanding this could affect how clinicians monitor and study vitamin D...

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Mistakes in the management of irritable bowel syndrome-diarrhoeal subtype and mimics: a narrative review.
Current medical research and opinion

Mistakes in the management of irritable bowel syndrome-diarrhoeal subtype and mimics: a narrative review.

People labelled with IBS-D may actually have treatable organic conditions that require different tests and treatments; avoiding diagnostic mistakes can speed appropriate care and reduce unnecessary symptom-focused...

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From Dysbiosis to systemic health: Microbiome modulation as a unified therapeutic framework.
Acta microbiologica et immunologica Hungarica

From Dysbiosis to systemic health: Microbiome modulation as a unified therapeutic framework.

The review connects microbiome-targeted therapies (diet, probiotics, FMT, antibiotics, and newer approaches) to mechanisms relevant to IBD and systemic health, highlighting why these strategies are of interest to...

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Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.
Materials today. Bio

Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.

IBD and other lower-GI disorders may benefit from oral hydrogel platforms that improve local drug delivery while deliberately engaging the gut microbiota. Understanding this research direction helps patients and...

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A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders
NIH RePORTER

A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders

A validated human peristaltic intestinal organoid model could make preclinical testing more predictive for drugs affecting gut motility and reduce reliance on animal models.

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Dietary patterns, gut microbiota, and gastrointestinal disorders: mechanistic insights into irritable bowel syndrome and inflammatory bowel disease.
Reviews on environmental health

Dietary patterns, gut microbiota, and gastrointestinal disorders: mechanistic insights into irritable bowel syndrome and inflammatory bowel disease.

Diet is a modifiable factor that appears to change the gut microbiome and may affect symptoms and inflammation in both IBS and IBD; understanding which patterns help could guide practical dietary advice.

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