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Mental health and quality of life

Anxiety, depression, fatigue impact, adherence, social life, and quality-of-life news.

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Understanding the Impact of Perceived Stigma on Healthcare Perception and Medication Utilization Among Black Individuals with Inflammatory Bowel Diseases
Digestive Diseases and Sciences

Understanding the Impact of Perceived Stigma on Healthcare Perception and Medication Utilization Among Black Individuals with Inflammatory Bowel Diseases

Perceived stigma may affect how Black people with IBD view their care and whether they stick with medications, which can influence disease management and outcomes. Understanding these links can point to targets for...

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Assessment of ChatGPT responses to nutrition queries of patients with inflammatory bowel disease
Scientific Reports

Assessment of ChatGPT responses to nutrition queries of patients with inflammatory bowel disease

AI chatbots are increasingly used for health information. If chatbot answers about IBD nutrition are inaccurate or hard to read, patients could be confused or misinformed. This study assesses those risks for ChatGPT-3.5.

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Using a Person-Centred Approach to Adapt a Digital Therapy for Inflammatory Bowel Disease (COMPASS-IBD).
Health expectations : an international journal of public participation in health care and health policy

Using a Person-Centred Approach to Adapt a Digital Therapy for Inflammatory Bowel Disease (COMPASS-IBD).

People with IBD often face mental-health challenges, stigma and unpredictability of symptoms. Adapting an established CBT-based digital programme with direct input from patients and clinicians can make the content more...

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Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression
Journal of Nanobiotechnology

Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression

The study presents a novel probiotic-based delivery system that targets both intestinal inflammation and anxiety/depression through the gut–brain axis, a potentially relevant concept for people with IBD who commonly...

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Nursing‐Led Support Across the Standard Care–Clinical Trial–Standard Care Pathway in Inflammatory Bowel Disease: A Review With Realist‐Informed Interpretation
PubMed Central

Nursing‐Led Support Across the Standard Care–Clinical Trial–Standard Care Pathway in Inflammatory Bowel Disease: A Review With Realist‐Informed Interpretation

Improving nursing support during IBD trial pathways could help people stay engaged, understand what participation involves, and report problems earlier—potentially making trials safer and more equitable.

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Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis
PLOS One

Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis

The study links worse UC activity with higher rates of anxiety and depression and with poorer quality of life among patients in Pakistan, suggesting mental-health screening could be relevant to overall disease...

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Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage.
Cellular & molecular immunology

Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage.

These results highlight a new cellular mechanism (macrophage-driven ECM changes) that may protect enteric neurons during intestinal inflammation — a process linked to symptoms and complications in IBD.

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Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study
Journal of Pediatric Gastroenterology and Nutrition

Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study

Parents and clinicians may wonder whether stressful events in early life increase a child’s long-term IBD risk. This large prospective study found no evidence that the measured early maternal or family adverse events...

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Inflammatory bowel disease and prostate cancer: from epidemiological controversy to mechanistic hypotheses
Frontiers in Immunology

Inflammatory bowel disease and prostate cancer: from epidemiological controversy to mechanistic hypotheses

People with IBD and their clinicians may be interested because some studies report higher prostate cancer incidence in IBD populations, and this review explores biological mechanisms that could explain a link while...

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A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy
ClinicalTrials.gov

A Novel Remote Patient and Medication Monitoring Solution to Improve Adherence and PerSiStence With IBD Therapy

The trial could show whether a smart-label app plus clinician alerts improves medication adherence and downstream clinical outcomes for people with Crohn's disease or ulcerative colitis starting oral or subcutaneous...

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Efficacy of psychotherapies in individuals with inflammatory bowel disease: A systematic review and meta-analysis
World Journal of Psychiatry

Efficacy of psychotherapies in individuals with inflammatory bowel disease: A systematic review and meta-analysis

The review shows psychotherapies can improve quality of life and reduce anxiety and depression in people with IBD, outcomes that matter for daily functioning even when intestinal symptoms may not change.

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Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis.
Alimentary pharmacology & therapeutics

Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis.

Itch is a frequent, often severe symptom in PSC that is linked to liver disease severity and worse quality of life. Recognizing and measuring pruritus matters because it significantly affects daily functioning and may...

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Self-Care and Illness Perception in Inflammatory Bowel Disease: Identifying Adaptive and Maladaptive Profiles Through Person-Centered Analysis
Psychiatric Quarterly

Self-Care and Illness Perception in Inflammatory Bowel Disease: Identifying Adaptive and Maladaptive Profiles Through Person-Centered Analysis

This study shows that people with IBD can display distinct self-care and illness-perception profiles rather than a single pattern; tailoring education and psychological support to these profiles could improve...

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Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn’s disease
Journal of Gastroenterology

Multimodal MRI reveals glymphatic system activity associated with systemic inflammation and neuropsychiatric symptoms in Crohn’s disease

This study suggests brain glymphatic function — a fluid-clearance system — may be altered in people with Crohn’s disease and could relate to inflammation and common neuropsychiatric symptoms like fatigue, anxiety,...

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Fatigue in inflammatory bowel disease beyond intestinal inflammation: A cross-sectional study.
Journal of psychosomatic research

Fatigue in inflammatory bowel disease beyond intestinal inflammation: A cross-sectional study.

Fatigue is common and disabling for people with IBD; this study shows that factors beyond intestinal inflammation—especially central sensitization and psychological symptoms—explain much of fatigue. That means treating...

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Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study
Mindfulness

Acceptability and Feasibility of Mindfulness-Based Cognitive Therapy in Adults with Inflammatory Bowel Disease: A Mixed-Methods Study

IBD patients often face high psychological burden; knowing whether MBCT is acceptable and feasible helps patients and clinicians weigh it as a support option. Practical barriers (time, fatigue, disease activity) and...

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Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study
Saudi Journal of Gastroenterology

Stigma management, social support, and quality of life among adults with Crohnʼs disease and ulcerative colitis in Saudi Arabia: A cross-sectional study

Stigma and social support appear to meaningfully relate to quality of life for adults with IBD in Saudi Arabia. Understanding which coping strategies and support sources help could inform patient education and support...

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Association of the DTI-ALPS Index with Sleep Disturbances and Intestinal Inflammation in Crohn's Disease: A Diffusion Tensor MRI Study.
Academic radiology

Association of the DTI-ALPS Index with Sleep Disturbances and Intestinal Inflammation in Crohn's Disease: A Diffusion Tensor MRI Study.

If confirmed, a brain perivascular/glymphatic change linked to intestinal inflammation could help explain why sleep problems are common in Crohn's disease and point to new research targets for symptom mechanisms and...

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Short-term psychiatric outcomes after ostomy vs nonostomy surgery in biologic-treated IBD patients.
Inflammatory bowel diseases

Short-term psychiatric outcomes after ostomy vs nonostomy surgery in biologic-treated IBD patients.

Short-term mental health problems (depression, anxiety, adjustment disorders) appear more common after ostomy creation than after nonostomy IBD surgery among biologic-treated adults. Awareness may help patients and...

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Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews
JCC Plus

Prevalence of Depressive Disorders in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta‐Analysis of Studies With Diagnoses Verified Using Structured Interviews

Depressive disorders—diagnosed using structured clinical interviews—appear to be relatively common in people with IBD, which has implications for screening and referral to mental health care within IBD clinics.

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Post-COVID-19 Condition has High Prevalence in Patients with Immune-mediated Inflammatory Diseases and Negatively Impacts Quality of Life
Journal of Global Infectious Diseases

Post-COVID-19 Condition has High Prevalence in Patients with Immune-mediated Inflammatory Diseases and Negatively Impacts Quality of Life

People with IBD and other immune-mediated inflammatory diseases may be at risk for lasting symptoms after COVID-19, and those symptoms were associated with worse quality of life in this study. Awareness can help...

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Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey.
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition

Multifaceted burden of short bowel syndrome for patients and caregivers: The landmark survey.

Patients with short bowel syndrome and their caregivers can face heavy, multidimensional burdens including dependence on parenteral nutrition/IV hydration, frequent symptoms like fatigue, increased healthcare use, and...

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Dietary Beliefs, Genetic Risk Perceptions, and Preventive Dietary Practices Among Unaffected First-Degree Relatives of Individuals with Inflammatory Bowel Disease: A Mixed Methods Study in Greece
Europe PMC

Dietary Beliefs, Genetic Risk Perceptions, and Preventive Dietary Practices Among Unaffected First-Degree Relatives of Individuals with Inflammatory Bowel Disease: A Mixed Methods Study in Greece

First‑degree relatives of people with IBD may worry about their own risk and consider diet as a way to reduce that risk. The study suggests how beliefs about genetics and diet influence whether relatives make preventive...

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Psychiatric disorders before and after inflammatory bowel disease diagnosis: a nationwide cohort study in Sweden 2007-2023.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Psychiatric disorders before and after inflammatory bowel disease diagnosis: a nationwide cohort study in Sweden 2007-2023.

Psychiatric disorders (especially depression, anxiety, and substance misuse) are more common in people with IBD starting a few years before diagnosis and remaining higher for years after. Recognizing this link can help...

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Ileostomy or Ileal Pouch Anal Anastomosis: Shared Decision-Making in the Surgical Management of Ulcerative Colitis.
Clinics in colon and rectal surgery

Ileostomy or Ileal Pouch Anal Anastomosis: Shared Decision-Making in the Surgical Management of Ulcerative Colitis.

Surgical choices for ulcerative colitis—permanent ileostomy versus ileal pouch (IPAA)—lead to very different daily-life outcomes. Understanding risks and lifestyle tradeoffs and using shared decision-making helps...

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