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Mental health and quality of life

Anxiety, depression, fatigue impact, adherence, social life, and quality-of-life news.

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Inflammatory bowel disease-rheumatology: evaluation of a collaborative, multidisciplinary, patient-centred care model
Frontline Gastroenterology

Inflammatory bowel disease-rheumatology: evaluation of a collaborative, multidisciplinary, patient-centred care model

Many people with IBD also have inflammatory joint disease. This combined clinic model aimed to provide simultaneous gastroenterology and rheumatology assessment and shared decision-making, and the study reports frequent...

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Waiting time for surgery and health-related quality of life in patients with inflammatory bowel disease
International Journal of Colorectal Disease

Waiting time for surgery and health-related quality of life in patients with inflammatory bowel disease

Long waits for IBD-related surgery were linked to poorer quality of life in this study, especially when waiting exceeded 1 year. That suggests delays could meaningfully affect daily functioning for people with Crohn’s or...

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Multimodal CCA + joint ICA reveals fused gray matter volume and resting-state functional alterations with neurotransmitter associations in Crohn’s disease
Journal of Translational Medicine

Multimodal CCA + joint ICA reveals fused gray matter volume and resting-state functional alterations with neurotransmitter associations in Crohn’s disease

This study links brain structure and function differences to clinical measures and neurotransmitter systems in Crohn’s disease, which may help explain cognitive, mood, or quality-of-life effects some people with CD...

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Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.
Frontiers in cellular neuroscience

Maladaptive sensory coding in the enteric nervous system playing a role in gastrointestinal disorders.

This review connects enteric sensory neuron dysfunction to symptoms common in IBS and IBD (pain, diarrhea, constipation, dysmotility). Understanding IPAN plasticity could point to new treatment targets that act locally...

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Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.
Patient preference and adherence

Knowledge, Attitude, and Practice in Inflammatory Bowel Disease: Associated Factors and the Mediating Role of Attitude.

Self-management is central to long-term IBD control. The study shows many patients have limited disease knowledge and less favorable attitudes, which could affect adherence, lifestyle choices, and follow-up.

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Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.
Autoimmunity reviews

Beyond the pelvis: redefining endometriosis as a systemic inflammatory disorder. A systematic review and meta-analysis.

If endometriosis is linked to other immune, allergic, or chronic pain conditions, people with endometriosis may benefit from broader evaluation and coordinated care beyond gynecology. The review suggests shared...

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Updated treatment targets in inflammatory bowel disease (STRIDE-III): an initiative of the International Organization for the Study of IBD.
The lancet. Gastroenterology & hepatology

Updated treatment targets in inflammatory bowel disease (STRIDE-III): an initiative of the International Organization for the Study of IBD.

Updated treat-to-target recommendations affect how inflammation and symptoms are monitored and when treatments should be changed. Clear targets and timing help patients and clinicians make consistent, evidence-informed...

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Gastrodin alleviates acute colitis with comorbid anxiety- and depression-like behaviours rather than cognitive dysfunction by modulating gut microbiota and suppressing inflammation.
Naunyn-Schmiedeberg's archives of pharmacology

Gastrodin alleviates acute colitis with comorbid anxiety- and depression-like behaviours rather than cognitive dysfunction by modulating gut microbiota and suppressing inflammation.

An experimental mouse study suggests gastrodin may reduce colitis severity and associated anxiety/depression-like behaviours while changing gut microbiota, metabolites, and intestinal inflammation — an early preclinical...

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HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)

HECTD1 Directs HIF-1α to Facilitate Intestinal Inflammation and Carcinogenesis via Promoting Th17 Differentiation and Glycolysis.

The study identifies a molecular mechanism that links immune cell metabolism (Th17 glycolysis) with intestinal inflammation and colitis-associated cancer in experimental models. That pathway could eventually yield new...

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Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.
Journal of psychosomatic research

Fatigue across physical and mental health conditions: results from a multicenter study at the German Center for Mental Health.

The study directly compares fatigue levels across several chronic conditions using the same validated tools, offering context for how fatigue in IBD compares to other illnesses. That context can help patients and...

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Defining and measuring disease burden in Crohn's disease: a systematic literature review.
Scandinavian journal of gastroenterology

Defining and measuring disease burden in Crohn's disease: a systematic literature review.

Patients and clinicians use the term "disease burden" to describe more than inflammation alone; it affects symptoms, daily function, mental health, and healthcare use. A clearer, integrated way to measure burden could...

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Digital cognitive behavioural self-management programme for fatigue, pain, urgency and incontinence in inflammatory bowel disease
Translational gastroenterology and hepatology

Digital cognitive behavioural self-management programme for fatigue, pain, urgency and incontinence in inflammatory bowel disease

Based on the title and source metadata, this appears to be an opinion or commentary related to Inflammatory bowel disease, Fatigue, and Pain. The original article is from Translational gastroenterology and hepatology.

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Dexpanthenol attenuates anxiety-like behaviors and inflammatory factors in a rat model of acetic acid-induced colitis
BMC Pharmacology and Toxicology

Dexpanthenol attenuates anxiety-like behaviors and inflammatory factors in a rat model of acetic acid-induced colitis

The study links an experimental treatment (dexpanthenol) to reduced inflammatory cytokines and improved anxiety-like behaviors in a rat colitis model, which is relevant to research on inflammation-driven gut–brain...

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New composite outcomes data show patients treated with Lilly's Omvoh (mirikizumab-mrkz) achieved comprehensive corticosteroid-free disease control in ulcerative colitis and ...
prnewswire.com

New composite outcomes data show patients treated with Lilly's Omvoh (mirikizumab-mrkz) achieved comprehensive corticosteroid-free disease control in ulcerative colitis and ...

These results suggest mirikizumab can achieve multiple treatment goals at once — symptoms, objective inflammation measures, and steroid-free status — outcomes that matter to people with IBD because they reflect both...

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Eating-related psychological burden and self-concordance in adults with inflammatory bowel disease: an online cross-sectional survey
BMC Gastroenterology

Eating-related psychological burden and self-concordance in adults with inflammatory bowel disease: an online cross-sectional survey

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Mental health and quality of life. The original article is from BMC Gastroenterology.

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Physical activity in individuals with inflammatory bowel disease: a Danish population-based repeated cross-sectional study.
Scandinavian journal of gastroenterology

Physical activity in individuals with inflammatory bowel disease: a Danish population-based repeated cross-sectional study.

Physical activity is linked to general health and quality of life. If people with IBD—particularly those with more severe CD—are less active, tailored support could help improve wellbeing and manage disease-related...

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Long-term Benefits of Mirikizumab on Patient-Reported Outcomes in Individuals with Crohn's Disease: 2-Year Results from the VIVID-2 Extension Study.
Clinical and translational gastroenterology

Long-term Benefits of Mirikizumab on Patient-Reported Outcomes in Individuals with Crohn's Disease: 2-Year Results from the VIVID-2 Extension Study.

Patients and clinicians considering long-term use of mirikizumab for Crohn's disease may find evidence here that quality of life and common symptoms (fatigue, abdominal pain, stool frequency) can remain improved out to...

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Health-related quality of life after diagnosis of ulcerative colitis and Crohn’s disease: 3-year trajectories and factors associated with clinically meaningful improvement (the IBSEN III cohort)
Inflammatory Bowel Diseases

Health-related quality of life after diagnosis of ulcerative colitis and Crohn’s disease: 3-year trajectories and factors associated with clinically meaningful improvement (the IBSEN III cohort)

This study follows people from diagnosis and shows that about half achieve clinically meaningful improvements in quality of life by 3 years, but many remain below general population norms.

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Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention
International Journal of Molecular Sciences

Chronic Ultrasound (‘Emotional’) Stress in Mice Exacerbates Colitis Through GSK3β-Mediated Neuroimmune Dysregulation and Is Ameliorated by Probiotic Intervention

The study suggests psychological (emotional) stress can worsen colitis-like inflammation via GSK3β-mediated neuroimmune changes, and that a probiotic (VSL#3) reduced many adverse effects in mice — relevant to...

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Inflammatory bowel disease and breast cancer: epidemiological evidence, shared biology, and clinical management.
Inflammation research : official journal of the European Histamine Research Society ... [et al.]

Inflammatory bowel disease and breast cancer: epidemiological evidence, shared biology, and clinical management.

This review addresses whether people with IBD face higher breast cancer risk and how treatments for one disease might affect the other—questions many patients and clinicians raise when cancer and IBD overlap.

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