Pain

This review connects enteric sensory neuron dysfunction to symptoms common in IBS and IBD (pain, diarrhea, constipation, dysmotility). Understanding IPAN plasticity could point to new treatment targets that act locally...

If validated, blood antibody patterns could allow earlier identification of people at risk for Crohn’s disease or ulcerative colitis — potentially before bowel damage occurs — opening opportunities for earlier monitoring...

Fatigue affects a large share of people with IBD and often persists despite remission; understanding treatment options and the need for a broad care plan can help patients and clinicians set realistic goals and...

Capsaicin is commonly consumed and acts on TRPV1, which is increased in inflamed IBD tissue; depending on dose and disease activity it may help or worsen inflammation and symptom-related pain.

OTC painkiller use is very common among people with IBD, and those with recent disease activity are more likely to use them frequently and to take them specifically for IBD-related pain. Knowing this can help clinicians...

Patients who present with new radiologic terminal ileitis sometimes develop Crohn’s disease. Identifying simple blood and imaging markers that predict who is at higher risk could help prioritize follow-up or specialist...

Unexplained mid‑esophageal ulcers with recurrent oral ulcers can reflect rare systemic inflammatory diseases such as gastrointestinal Behçet disease, and they often need broad testing to exclude infections, malignancy,...

PSC patients commonly experience multiple symptoms that meaningfully affect mental and physical quality of life. Recognizing and measuring total symptom burden could improve research and clinical attention to...

The criteria were tested specifically in patients with psoriasis, uveitis, or IBD presenting with chronic back pain—groups at higher risk of axSpA—so results inform how well the new criteria perform in these real‑world...

Severe ulcerative colitis can be linked to rare cardiac rhythm disturbances; recognizing bradycardia during flares may prompt appropriate evaluation and monitoring. The case signals clinicians to consider cardiac causes...

Disability related to IBD affects daily functioning and quality of life; identifying factors linked with higher or lower disability (vitamin D status, azathioprine use, smoking) can help patients and clinicians consider...

If you have IBD and joint symptoms, this study suggests your joint complaints may reflect measurable immune changes that partly overlap with spondyloarthritis, not just non-specific pain. That could mean joint symptoms...

Fear of movement was more common and more severe in people with ulcerative colitis in this study. Addressing kinesiophobia could help increase physical activity and improve function and quality of life for people with...

Strictures raise the risk that food will get stuck and cause a dangerous blockage. Simple changes to texture, portion size, and eating habits can lower that risk and help you keep a varied diet.

Children with IBD can have persistent gut–brain interaction symptoms even when inflammation is quiescent; these symptoms are linked with worse quality of life and higher anxiety. Recognizing DGBI-like symptoms may help...

A majority of surveyed IBD patients who use marijuana reported better quality of life and relief from symptoms such as nausea, joint pain, insomnia and anxiety — findings of interest to people seeking symptom management...

Chronic pain affects many people with IBD even after inflammation is controlled, often limiting daily activities and worsening mental health. Understanding that pain can persist without active inflammation highlights the...

Endometriosis involving the intestine can mimic Crohn’s disease symptoms and lead to misdiagnosis or delayed correct treatment. Patients with IBD-like symptoms who are of reproductive age may need evaluation for bowel...

Women with Crohn’s can face specific reproductive, sexual, and body-image issues that affect quality of life and pregnancy planning. Understanding how disease activity and medications interact with fertility and...

Noninfectious (aseptic) abscesses or persistent lymphadenitis can be an early extraintestinal sign of IBD in children. Recognizing this link can prompt appropriate imaging and endoscopic evaluation that may lead to...

This study suggests LVV can occur in people with IBD at younger ages and with distinct vascular findings, and it may arise even when gut disease is in remission. That matters for awareness, diagnosis, and coordination...

People with Crohn’s often have other inflammatory or immune-related conditions. Knowing these links can help patients and clinicians watch for symptoms that might need evaluation or treatment.

The study points to a specific gut microbe, Mediterraneibacter gnavus, that may be linked to joint inflammation in people with Crohn's disease. If confirmed, a microbial biomarker could help identify who is at risk for...

Vulvar Crohn’s is an uncommon but real extraintestinal manifestation that can cause painful skin changes and sometimes appears before GI Crohn’s is diagnosed. Knowing about it may speed diagnosis and lead to coordinated...

Many people with Crohn’s disease continue to have symptoms even when inflammation is absent. This study suggests the gut microbiome — specifically sulfur-producing bacteria and hydrogen sulfide production — might explain...