Tests and monitoring tools
Biopsy articles covering tissue sampling, diagnosis, inflammation assessment, dysplasia surveillance, and IBD research findings. Monitoring context emphasizes diagnosis, follow-up, disease activity, treatment response, and care decisions.
41 articles
A reusable transcriptomic atlas could let researchers compare new IBD biopsy datasets to a common reference, improving cross-study comparisons and helping separate inflammation from persistent disease-state biology that...
A rapidly growing abdominal mass or unexplained systemic decline in someone with Crohn's disease may represent a rare malignancy (plasmablastic neoplasm) rather than infection or a disease flare; prompt biopsy is...
Predicting who will relapse after stopping anti-TNF drugs could help avoid unnecessary flares or unnecessary ongoing treatment. A biopsy-based transcriptomic test could be a useful decision tool if validated.
If validated, mucosal biomarkers like SPARC and SPP1 might help predict who will not respond to infliximab, potentially guiding treatment choices and avoiding ineffective therapy for some people with UC.
Researchers are testing whether blocking three inflammation pathways at once can reduce tissue inflammation more than single drugs. If ex vivo results show stronger effects, it could guide development of multi-target...
The study aims to map the specific peptide targets of T cells driving organ inflammation in autoimmune diseases, which could guide development of antigen-specific, tolerogenic treatments relevant to Crohn's disease and...
Patients and clinicians struggle to predict relapse in ulcerative colitis because current endoscopic, histologic, and noninvasive biomarkers are imperfect. A tissue-based imaging and spatial-omics approach could identify...
Better endoscopic classification of flat-type dysplasia could improve surveillance accuracy for people with long-standing ulcerative colitis, helping identify lesions that need biopsy or more urgent management.
Knowing biomarkers that predict who will respond to IL23 p19 inhibitors could help people with IBD avoid trial-and-error therapy choices. Understanding whether increasing risankizumab dosing after loss of response...
A quantitative, biopsy-based measure of collagen architecture could help study intestinal fibrosis, which underlies stricture formation in Crohn’s disease. Feasibility data support further validation work that may lead...
People with stricturing Crohn’s disease currently lack effective medical treatments to prevent or reverse intestinal fibrosis; this trial explores a probiotic approach (and trehalose) aimed at stimulating autophagy, a...
Distinguishing UC from Crohn’s colitis can be challenging but affects long-term management and surveillance. A histologic feature—homogeneity versus heterogeneity of epithelial lesions across biopsies—might help improve...
The study shows that mucosal CD3+ T‑cell density is higher in dogs with an IBD-like condition than in healthy dogs, suggesting mucosal T‑cell infiltration is part of the disease but may not reflect how sick an individual...
People with Crohn's disease who develop symptomatic intestinal strictures currently often need endoscopic dilation or surgery. This trial tests an investigational oral drug (ontunisertib) aiming to improve...
Early-phase mechanistic trials test how a new drug affects disease biology and safety; results can help decide whether larger trials should follow.
The project aims to enable simultaneous RNA-level profiling of microbes and host cells from human biopsies, which could reveal early microbial and host gene-expression patterns linked to subclinical Crohn’s disease and...
Unexplained mid‑esophageal ulcers with recurrent oral ulcers can reflect rare systemic inflammatory diseases such as gastrointestinal Behçet disease, and they often need broad testing to exclude infections, malignancy,...
Distinguishing IBD from gastrointestinal tuberculosis is challenging in regions where GITB is common; histologic markers like basal plasmacytosis and eosinophilia on mucosal biopsy could help guide diagnosis when...
In young children, enteric infections can mimic or coexist with VEO‑IBD and change imaging and clinical findings; recognizing both can affect diagnosis and treatment choices.
GI infections—especially CMV—were common in this study and much more frequent in acute severe UC than in remission, suggesting testing for infections can change diagnosis and management during severe flares.
Pouchitis is a common complication after IPAA and noninvasive tools to detect inflammation could make monitoring easier and less burdensome than repeated pouchoscopy. This trial tested whether intestinal ultrasound can...
AI models that combine CTE/MRE imaging with clinical and molecular data could improve objective classification of small-bowel Crohn's disease and help predict which patients are likely to respond to medical therapy...
Patients and clinicians may care because the study suggests contrast-enhanced CT can reliably detect and localize IBD, including transmural and small-bowel disease that biopsies miss, which could affect diagnostic...
Early-phase trials test safety and tolerability of new mechanisms; this study evaluates an anti–IL-18 antibody (aletekitug) which could represent a different therapeutic approach for people with moderate-to-severe UC if...
If confirmed, an endocytoscopic appearance that corresponds to a specific miRNA and chemokine pattern could help clinicians assess mucosal inflammation during colonoscopy and prioritize biopsies or treatment decisions...
People with IBD may have a higher-than-expected rate of biopsy-confirmed celiac disease in this Northern Indian cohort, and standard anti-tTG blood tests can be falsely positive in IBD. Confirmatory duodenal biopsy is...
People with UC can develop severe neutrophilic skin complications like Sweet’s syndrome that may reflect active bowel inflammation even when recent tests suggested remission.
An infectious cause (amebic colitis) can mimic IBD on colonoscopy and imaging, even without symptoms; misdiagnosis could delay correct treatment.
This report shows intestinal tuberculosis can present like inflammatory bowel disease with lower GI bleeding, leading to diagnostic delay; correct identification allowed targeted anti-TB and HIV therapy and clinical...
Granulomas are a classic histologic feature of Crohn’s disease, so patients and clinicians may wonder whether their presence predicts worse disease or different treatment needs. This review shows existing studies are...
Endoscopy in this pediatric multicenter series found a high diagnostic yield and confirmed IBD and other treatable conditions; this matters for families and clinicians in resource-limited settings because improving...
CMV reactivation can worsen outcomes in active UC and influence treatment choices; clinicians and patients may benefit from additional, easy-to-measure markers that flag higher risk of tissue CMV and prompt targeted...
Colorectal lymphoma in children can mimic IBD flares or cause surgical emergencies; recognizing this can prevent inappropriate escalation of immunosuppression and speed correct diagnosis and treatment.
The atlas maps which genes and cell types are different in Crohn's disease, offering clues about why inflammation persists and pointing to specific immune pathways (like JAK/STAT) that are already drug targets. The...
Mucosal healing is a treatment goal that aims to stop internal intestinal inflammation, not just symptoms. Achieving mucosal healing is linked with fewer hospitalizations, less need for surgery, and lower rates of...
The episode clarifies key differences between Crohn’s and ulcerative colitis, outlines common symptoms that should prompt medical evaluation, and reviews monitoring and complication risks that affect long‑term care.
The article explains how gut bacteria may contribute to IBD and summarizes common tests and treatments people are likely to encounter. It highlights emerging microbial therapies (probiotics and FMT) that some patients...
Noninfectious (aseptic) abscesses or persistent lymphadenitis can be an early extraintestinal sign of IBD in children. Recognizing this link can prompt appropriate imaging and endoscopic evaluation that may lead to...
IBD can present in uncommon ways in children — including as an intraluminal abdominal mass that mimics tumors. Early recognition avoids misdiagnosis and guides appropriate surgical and medical follow-up.
Vulvar Crohn’s is an uncommon but real extraintestinal manifestation that can cause painful skin changes and sometimes appears before GI Crohn’s is diagnosed. Knowing about it may speed diagnosis and lead to coordinated...
Skin patches and other non‑digestive symptoms can be part of Crohn's disease and may prompt further evaluation. Knowing these signs could help people seek earlier assessment from a GP.
