Cure8 trial brief
Pouchitis is a common complication after IPAA and noninvasive tools to detect inflammation could make monitoring easier and less burdensome than repeated pouchoscopy. This trial tested whether intestinal ultrasound can identify abnormal pouch inflammation compared with pouchoscopy plus biopsies.
Clinicians; radiologists; researchers; adult patients with IPAA; caregivers interested in less-invasive pouch monitoring
This is a completed interventional clinical study (registered at ClinicalTrials.gov) testing intestinal ultrasound (IUS) — transabdominal and transperineal — to evaluate pouch inflammation (pouchitis) in adults with ulcerative colitis who have undergone ileal pouch–anal anastomosis (IPAA).
The study aimed to establish normal sonographic parameters for a healthy pouch and to compare IUS diagnostic accuracy against the gold standard pouchoscopy with biopsies. Radiologists interpreting the ultrasounds were blinded to pouchoscopy results.
The trial enrolled up to 66 adults at Mayo Clinic (Rochester, MN); key exclusions included BMI >30, pregnancy, indeterminate colitis, and IPAA for FAP. Primary outcomes focused on diagnostic accuracy and the number of participants with abnormal ultrasound findings confirmed by pouchoscopy/biopsy.
The registered time frame for the ultrasound procedure was about 2 hours per subject. This record reports the study design and aims (trial-record level). It does not present trial results, effect sizes, or outcome data in the supplied text, so no conclusions about IUS performance can be drawn from this registry entry alone.
Registry entry describes study design and aims but does not report results. Some eligibility exclusions (BMI >30, FAP) may limit applicability to all pouch patients.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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