Imaging

Accurate diagnosis and classification affect treatment choices and risks—misdiagnosis can lead to unnecessary immunosuppression, while misclassification can under-recognize severe or proximal disease that needs different...

People with Crohn’s disease who have had, or will have, intestinal surgery may benefit from better tools to predict early complications and endoscopic recurrence. Predictive models could help tailor follow-up and...

Distinguishing inflammation from irreversible fibrosis is a common clinical challenge in Crohn’s disease because it affects treatment choices (medical therapy versus surgery). Validated MRI biomarkers could improve...

The study suggests Crohn’s disease is associated with coordinated brain structure and function differences that relate to disease activity and quality of life, pointing to brain–gut links that could inform future...

The study offers a validated tool to estimate risk of postoperative recurrence after ileocolonic resection and shows that postoperative biologic prophylaxis markedly lowers early endoscopic recurrence—information that...

Perianal fistulas are a common, debilitating complication of Crohn’s disease; longer-term data on treatments that can produce durable fistula remission are directly relevant to patients and clinicians managing this...

Fibrostenotic strictures are a major unmet need in Crohn’s disease because anti-inflammatory drugs often cannot reverse established scarring; IL-11 is a biologically plausible target that might selectively affect...

Fatigue is a common, disabling issue in Crohn’s disease with unclear biology. This study suggests measurable brain-structure differences correlate with fatigue severity and may modify how disease activity influences...

MRE is a widely used, noninvasive test that increasingly helps characterize disease phenotype and prognosis in Crohn's disease and IBD, which can affect monitoring and treatment planning.

Predicting early need for infliximab could help identify children with Crohn’s disease who may benefit from earlier biologic therapy instead of prolonged conventional treatment. A reliable prediction tool may shorten...

Noninvasive imaging that better separates inflammation from fibrosis and detects penetrating complications could change monitoring and treatment decisions in IBD and reduce radiation exposure for patients needing...

The study points to a possible noninvasive brain-based biomarker that correlates with intestinal fibrosis severity in Crohn’s disease, a complication that’s hard to detect and treat. This could eventually help identify...

AMNs are rare but can be malignant and may mimic UC flares or appendicitis, which can delay diagnosis. For people with long-standing UC, awareness may prompt appropriate imaging and surgical referral.

The study suggests pulmonary nodules are more common in people with Crohn’s disease and that age and certain medications (not disease phenotype) may better predict nodule burden — information that could influence how...

Distinguishing Crohn’s disease from appendicitis is a common and important diagnostic problem. Objective CT measurements could help reduce subjective interpretation and guide correct diagnosis, but this study shows...

Accurate, consistent severity grading at diagnosis shapes initial treatment decisions in Crohn’s disease. AI that can reproduce expert severity assessments from small labeled datasets could help standardize grading and...

Pulmonary nodules appear more frequently in people with Crohn’s disease and have distinct patterns over time. Knowing which factors predict nodule burden can help clinicians prioritize monitoring and interpret chest...

A platform trial could evaluate multiple advanced therapies and combinations more efficiently, which matters for people with refractory Crohn's disease who have already tried several advanced treatments.

A new chemiluminescent probe could help researchers see and measure MPO-driven HOCl inflammation deeper in tissues, which may speed preclinical testing of IBD therapies and biomarker development.

Transmural healing on CT enterography was associated with fewer hospitalizations over long follow-up, which could matter for long-term disease management and monitoring strategies in Crohn’s disease.

This case series points to risankizumab as a potential option for children with IBD who have failed multiple biologics, and it reports use of noninvasive monitoring like intestinal ultrasound.

The article reports a new oral nanozyme that combines imaging and ROS-scavenging therapy aimed at IBD lesions—an early-stage approach that could one day enable targeted, noninvasive treatment and lesion tracking.

If validated, AI-enhanced vascular assessment during endoscopy could give clearer, more reproducible information about mucosal and histologic healing — which matters for monitoring disease activity and guiding treatment...

AI-assisted detection tools and disease-specific optical classifications could improve lesion detection and real-time characterization during UC surveillance, potentially affecting surveillance accuracy and...

Perianal fistulas are a common, hard-to-heal complication of Crohn's disease. This review collects current options beyond infliximab and explains where evidence is stronger or still emerging, which can help patients and...

This study provides real-world evidence about using upadacitinib as a maintenance therapy in children with refractory Crohn’s disease — a group with limited treatment options.

A bibliometric map of perianal fistula research helps patients and clinicians see how much work exists, which centers and authors lead the field, and which topics cluster together—useful when looking for expertise or...

A colon-targeted, enzyme-activated imaging probe could help distinguish early versus late inflammatory stages in IBD and provide a noninvasive fecal fluorescence signal—potentially improving disease monitoring beyond...

Non-invasive imaging biomarkers that track intestinal inflammation and structure could speed preclinical testing of IBD therapies and guide translational imaging research relevant to clinical monitoring of ulcerative...

Early prediction of who will not respond to infliximab could help clinicians avoid prolonged ineffective treatment, enabling earlier reassessment and changes in therapy as part of treat-to-target care.

A new fluorescent probe designed from bile acids may help image inflammation and has shown anti-inflammatory/antioxidant activity in cell studies relevant to ulcerative colitis, which could inform future diagnostic or...

Noninvasive detection of intestinal fibrosis activity could help identify patients at risk of progressive scarring and surgery, and enable development or targeting of anti-fibrotic treatments for Crohn's disease.

If you're living with Crohn's disease, earlier and better diagnosis (for example, more cross-sectional imaging) may partly explain falling surgery rates over time. This study suggests system-level diagnostic improvements...

Postoperative recurrence is common after intestinal resection for Crohn's disease, but clinicians currently lack reliable molecular biomarkers or validated models to predict who will relapse.

MRE is a key radiation-free imaging tool for children with Crohn’s disease; this review summarizes its clinical utility and how it fits with other pediatric-focused diagnostic approaches in Japan.

Baseline MRE features may help predict which Crohn's strictures will not improve with advanced medical therapy, informing monitoring and surgical planning. Better stratification could guide decisions about earlier...

Transmural healing may better reflect the full depth of inflammation in Crohn’s disease than mucosal healing alone and is associated with improved long-term outcomes in many studies. If validated and adopted, TH could...

Patients and clinicians struggle to predict relapse in ulcerative colitis because current endoscopic, histologic, and noninvasive biomarkers are imperfect. A tissue-based imaging and spatial-omics approach could identify...

A single agent that both highlights inflamed colon tissue on MRI and delivers anti-inflammatory therapy could improve how ulcerative colitis is monitored and treated, reducing reliance on metal contrast agents.

Imaging found increased visceral fat in children with Crohn's despite normal BMI, which could reveal inflammation-related risk not apparent from weight alone. Visceral adiposity was linked to markers of inflammation and...

This study shows that sodium butyrate, a metabolite produced by gut bacteria, changed brain imaging measures and reduced inflammation in mice with experimental IBD, supporting the idea that gut-derived compounds can...

Patients who present with new radiologic terminal ileitis sometimes develop Crohn’s disease. Identifying simple blood and imaging markers that predict who is at higher risk could help prioritize follow-up or specialist...

Identifies a molecule (CCL3) linked to more severe inflammation in IBD tissues, which could help researchers develop new biomarkers or treatments targeting immune-cell recruitment and polarization.

A quantitative, biopsy-based measure of collagen architecture could help study intestinal fibrosis, which underlies stricture formation in Crohn’s disease. Feasibility data support further validation work that may lead...

Fibrosis and stricture formation are important complications in Crohn’s disease; a biopsy-based, quantitative way to measure collagen architecture could help research into fibrotic disease mechanisms and eventually...

Psoriasis and Crohn’s disease share immune pathways that affect treatment choices. Some biologics work across both conditions while others (notably IL-17 inhibitors) may be inappropriate for patients with active IBD.

Researchers are exploring ways to deliver drugs selectively to inflamed gut tissue in IBD to boost local effectiveness and reduce systemic side effects. Progress in smart nanoparticles and hydrogels could eventually...

People with IBD have higher risk of several GI and hepatobiliary cancers; imaging is an important complement to endoscopic surveillance for detecting cancers that may be transmural or outside endoscopic reach.