ClinicalTrials.gov
Cure8 trial brief
Prediction of Postoperative Recurrence in Crohn's Disease
Research and clinical trials
Microbiome
Biomarkers
Imaging
Biomarker
Bowel Resection
Abdominal Pain
Diarrhea
Why This Matters
Postoperative recurrence is common after intestinal resection for Crohn's disease, but clinicians currently lack reliable molecular biomarkers or validated models to predict who will relapse.
This study aims to build and validate a multimodal prediction model using tissue and multi-omics data, which could help tailor postoperative monitoring and therapy in the future.
Who Should Pay Attention
Adults with Crohn's disease facing intestinal resection, patients in the early postoperative period, clinicians managing postoperative IBD care, and researchers interested in multi-omics biomarkers and predictive modeling.
Study Snapshot
Story typeClinical Reference
Evidence typeClinical trial
Enrollment250 participants
Study statusRecruiting
Source depthTrial registry record
What To Know
This is a multicenter prospective observational cohort study recruiting adults with Crohn's disease who undergo clinically indicated intestinal resection.
The study will collect residual surgical tissue and serial clinical and biological samples to perform multi-omics profiling (including bulk and single-cell transcriptomics, spatial transcriptomics, proteomics, microbiome, and metabolomics).
Data from a screening cohort will be used to build a machine-learning multimodal prediction model for postoperative recurrence; a separate validation cohort will test model performance. No treatments are assigned by the protocol; clinical care is per treating physicians.
The record describes planned clinical, endoscopic, and imaging follow-up to define postoperative recurrence and lists primary and secondary outcome timeframes. The study also includes a non-IBD control group undergoing intestinal resection for other reasons for comparative molecular analyses.
Because this is a trial registry entry (trial-record), the note summarizes the study design and goals without implying results. Participants should expect standard clinical care and separate research sample collection only.
Keep In Mind
This is an observational, non-randomized registry study recruiting participants; it describes planned sample collection and analyses but does not report results. Findings, if produced, would require peer review and independent validation before changing clinical practice.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorSixth Affiliated Hospital, Sun Yat-sen University
Trial IDNCT07824791
Study typeObservational
Enrollment250 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedSep 17, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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