Single-cell sequencing

The review evaluates a revised preprint linking GM-CSF, macrophages, and ILC-like cells in Crohn’s disease using human spatial transcriptomics and zebrafish experiments. It highlights limitations that matter because they...

This study uses transcriptomics, single‑cell data, and machine learning to nominate lactylation‑related genes as biomarkers and drug targets in ulcerative colitis, which could guide future biomarker or drug‑repurposing...

The paper suggests a specific molecule, MXRA7, links macrophage M1 polarization and epithelial pyroptosis—two processes implicated in ulcerative colitis tissue damage. If validated, this could point to new targets for...

The study points to a specific microbiome-derived micronutrient pathway (queuosine/queuine) that appears reduced in IBD, which could help explain part of microbiome-related changes in intestinal cells and suggest new...

TG2 produced by intestinal myofibroblasts may drive fibrosis and strictures in Crohn's disease independently of inflammation; blocking TG2 reduced fibrosis in lab and mouse models, pointing to a possible new...

This study helps pinpoint which gut cell types and regulatory DNA regions are most likely to mediate genetic risk for Crohn’s disease, which can guide future research toward relevant cells and pathways.

The paper points to S100A8 as a potential link between immune-cell-driven inflammation and mitochondrial stress in Crohn’s disease, which could help researchers explore new biomarkers or targets for study.

This study proposes three autophagy-related genes (APOL1, CCL2, IL24) as potential biomarkers that may help classify ulcerative colitis patients into subtypes with different immune environments, which could eventually...

This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...

The paper suggests a molecular link (RHBDF2–ADAM17–TNFα) between ulcerative colitis and blood–brain barrier disruption, which could explain some neurological comorbidities of UC and identify targets for future therapies.

The study identifies a molecular epithelial program (GART-associated) linked to proliferation and purine metabolism in ulcerative colitis, which could inform future mechanistic research and biomarker development relevant...

Understanding whether innate lymphoid cells retain ‘memory’ that drives psoriasis relapse could reveal biomarkers to monitor recurrence and suggest new therapeutic targets for patients with recurrent disease.

New biomarkers and cell-type insights could help future diagnostic tools or targeted therapies in UC by pointing to TRP channel–related genes and B/plasma cell involvement.

This study describes a novel, non‑drug HA‑based nano‑assembly that targets inflammatory M1 macrophages and reshapes the colonic immune environment in mouse models of ulcerative colitis — a potential new therapeutic...

Researchers are studying how gut bacteria evade therapeutic phages, which could affect development of phage-based treatments for drug-resistant infections and potentially influence understanding of bacteria linked to IBD...

The study suggests stromal fibroblasts can drive pro-inflammatory neutrophil programs in ulcerative colitis and that targeting fibroblast-associated pathways may reduce neutrophil-driven inflammation—information that...

Identifies a fibroblast senescence signature and highlights ADAMTS2 as a candidate biomarker linked to inflammation and fibrosis in IBD, which could guide future diagnostic or therapeutic research relevant to Crohn’s...

A blood biomarker that flags higher risk for complicated Crohn's could help identify people who may need closer monitoring or earlier treatment escalation before clear symptoms or endoscopic inflammation appear.

The paper proposes molecular links between Crohn’s disease and Alzheimer’s disease through two genes implicated in inflammation and tissue remodeling. This could shape future research into shared gut–brain inflammatory...

The pipeline helps identify stem and progenitor epithelial cell states linked to inflammation in IBD. Knowing these cell states and biomarkers could guide research into disease mechanisms, tissue repair, and potential...

Accurate methods and dataset labels matter for researchers reproducing transcriptomic analyses and for clinicians interpreting translational implications. The corrigendum clarifies which datasets and experimental models...

Researchers identified COPZ1 as a shared ferroptosis-related hub gene in Crohn’s disease, ulcerative colitis, and periodontitis, which could point to a new molecular pathway linking gut and oral inflammation and a...

Identifies a stromal-cell subset marked by TIMP1 that may play a role in UC pathogenesis and might serve as a candidate biomarker or therapeutic target; useful for researchers and clinicians following emerging...

Researchers are studying a parasite-derived protein (Fh15) that may reduce neutrophil-driven inflammation in sepsis and ulcerative colitis models; this could point toward new anti-inflammatory drug approaches in the...

Macrophage behavior and metabolic reprogramming help drive inflammation or repair in ulcerative colitis, so understanding these processes could point to new therapies. The review links lab methods and ongoing clinical...

This study builds a large, public single-cell map of the gut in Crohn’s disease that identifies cell types and gene programs linked to inflammation. That can help researchers find new drug targets and explain why some...

A blood test (serum REG3α) may help identify people at higher risk of developing complicated Crohn's disease years before diagnosis and predict progression in established disease, which could inform monitoring or early...

The work highlights macrophage metabolic programs and specific genes that may help classify UC molecular subtypes and suggest candidate biomarkers or therapeutic targets related to macrophage-driven inflammation.

Identifies mast-cell–derived IL-13 as a likely contributor to intestinal fibrosis in Crohn disease, a complication not reliably prevented by current anti-inflammatory treatments. The finding points to a specific immune...

This study maps cell types in newly diagnosed pediatric Crohn's and links diagnostic cell patterns to disease severity and anti‑TNF treatment response. That could help predict which children are likely to benefit from...

A cellular atlas that links diagnostic biopsy cell states to treatment outcomes could help predict which children are likely to have severe or anti‑TNF‑resistant Crohn's disease, informing future research on personalized...

This study maps cell-level signatures in newly diagnosed pediatric Crohn’s and links them to later severity and responses to anti-TNF treatment, which could help predict which children will respond to biologic therapy...

Identifying baseline cellular states that predict disease course or response to anti‑TNF could help researchers develop predictive biomarkers and new therapeutic strategies for pediatric Crohn’s disease.

If you or someone you care for is not responding to anti‑TNF drugs for ulcerative colitis, this review explains biological reasons why that may happen and points toward research directions that could lead to better tests...

Researchers identified molecular features of a proposed “ferro‑aging” state in UC and nominated CHST15 and MSN as biomarkers, which could help understand disease biology and point to new experimental targets for therapy...

The paper proposes ISG20 as a shared molecular link between RA and IBD, which could help explain why the two diseases co-occur and point to a candidate biomarker for identifying patients at risk of both conditions.

The study points to CD226 (DNAM-1) being linked to inflammatory and interferon-driven programs in specific intestinal immune cells in Crohn's disease, which may be relevant to understanding disease mechanisms or...

The study describes a new molecular axis (Uhrf1 → PKM2 ubiquitination) that reduced inflammation and pyroptosis in IBD models and identifies a compound (EPT) that promotes this interaction — a potential early-stage...

The study describes a mechanism by which Huaier granules reduced colitis-related inflammation in mice and cell models by targeting macrophage cGAS–STING signaling and altering the gut microbiome—information that could...

This model could improve how researchers study IBD inflammation and early colorectal cancer in a human-derived, multicellular system that reproduces neuromuscular function and immune responses. That may speed preclinical...

If validated, IGFBP5 or its downstream pathway could help predict who will not respond to anti-TNF therapy and point to new targets to overcome resistance.

The study points to a specific immune cell type (pro-inflammatory CD4+ macrophages) and altered cellular interactions in rectal tissue that are linked to perianal fistulizing Crohn's disease, which may help explain...

The paper maps distinct stromal cell states tied to inflamed versus fibrotic tissue niches in Crohn’s disease and shows that these states have different chromatin configurations and drug-modifiable properties — pointing...

The study links shared gene-expression patterns between IBD and ankylosing spondylitis and highlights STAT3 as a potential shared biomarker or therapeutic target, which could be relevant for understanding overlapping...

The study suggests anti-TNF failure in Crohn's may be driven by pre-existing cytokine interaction networks and loss of regulatory feedback, which could help explain why some patients don't respond to TNF-blocking...

Researchers used genetics plus single-cell sequencing and ELISA to prioritize plasma protein ratios that may causally relate to ulcerative colitis. If validated in larger studies, such biomarkers could help with...

This study links blood gene signatures shared between Parkinson’s disease and intestinal inflammation to astrocyte-associated molecular changes in the brain, identifying HSP90AA1 as a candidate stress-responsive hub.

Researchers aim to create computational tools to identify cell–cell signaling that controls the mix of epithelial cell types in mucosal tissues. For IBD, such tools could help reveal signals that change intestinal...