Condition

Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 1 of 53 · 2506 articles

A Multi-marker Model Based on Routine Laboratory Parameters for Predicting Intestinal Fibrosis in Crohn's Disease
British Journal of Healthcare and Medical Research

A Multi-marker Model Based on Routine Laboratory Parameters for Predicting Intestinal Fibrosis in Crohn's Disease

The study suggests commonly available lab tests might help identify intestinal fibrosis and strictures in Crohn’s disease using a five-marker blood-based model, which could offer a noninvasive screening option if...

Read Summary
Perianal fistulizing Crohn's disease increases infliximab clearance and causes low infliximab exposure (ATLANTIC).
Journal of Crohn's & colitis

Perianal fistulizing Crohn's disease increases infliximab clearance and causes low infliximab exposure (ATLANTIC).

If you have Crohn’s disease with perianal fistulas and are treated with infliximab, this study suggests the drug is cleared faster and trough levels are often lower after standard dosing — which may mean you need higher...

Read Summary
Serum X-C Motif Chemokine Ligand 1 Is Associated with Endoscopic Activity in Crohn's Disease: A Clinical Biomarker Study.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Serum X-C Motif Chemokine Ligand 1 Is Associated with Endoscopic Activity in Crohn's Disease: A Clinical Biomarker Study.

Patients and clinicians want blood or noninvasive tests that reflect what is seen on colonoscopy. This study identifies XCL1 as a blood biomarker candidate associated with endoscopic activity in Crohn's disease, though...

Read Summary
Pitfalls in the Diagnosis and Classification of Crohn's Disease: Misdiagnosis, Overdiagnosis, and Misclassification.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Pitfalls in the Diagnosis and Classification of Crohn's Disease: Misdiagnosis, Overdiagnosis, and Misclassification.

Accurate diagnosis and classification affect treatment choices and risks—misdiagnosis can lead to unnecessary immunosuppression, while misclassification can under-recognize severe or proximal disease that needs different...

Read Summary
Validation and Reliability of the Turkish Version of the Inflammatory Bowel Disease-Disk in Patients with Inflammatory Bowel Disease.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

Validation and Reliability of the Turkish Version of the Inflammatory Bowel Disease-Disk in Patients with Inflammatory Bowel Disease.

Validated patient-reported measures help track how IBD affects daily function and well-being. A Turkish IBD-Disk gives clinicians and researchers a standardized way to measure patient-perceived disease burden and monitor...

Read Summary
Risk factors for postoperative intra-abdominal abscess following minimally invasive ileocecal resection in children with Crohn's disease.
Surgical endoscopy

Risk factors for postoperative intra-abdominal abscess following minimally invasive ileocecal resection in children with Crohn's disease.

Postoperative intra-abdominal abscesses are a common, serious short-term complication after ileocecal surgery in children with Crohn’s disease and can lengthen hospital stay and delay restarting medical treatment.

Read Summary
Upadacitinib in Colonic Crohn's Disease: A Narrative Review of Mechanistic Rationale, Clinical Trial Evidence, and Real-World Outcomes.
Middle East journal of digestive diseases

Upadacitinib in Colonic Crohn's Disease: A Narrative Review of Mechanistic Rationale, Clinical Trial Evidence, and Real-World Outcomes.

Upadacitinib is an approved oral JAK1 inhibitor with evidence for inducing and maintaining remission in moderate-to-severe Crohn's disease, including colonic-predominant disease. Patients and clinicians may consider it...

Read Summary
Subcutaneous versus intravenous double-dose infliximab for dose intensification in young adults with Crohn's disease: a prospective comparative study.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Subcutaneous versus intravenous double-dose infliximab for dose intensification in young adults with Crohn's disease: a prospective comparative study.

This study addresses a common problem in Crohn's patients on infliximab: low drug levels despite IV dosing. It suggests switching to a subcutaneous infliximab formulation can raise and stabilize trough concentrations...

Read Summary
Integrated multi-omics reveals a probiotic-enriched microbiome–metabolome axis associated with hPMSC therapeutic effects in Crohn’s disease
Stem Cell Research & Therapy

Integrated multi-omics reveals a probiotic-enriched microbiome–metabolome axis associated with hPMSC therapeutic effects in Crohn’s disease

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Stem Cell Research & Therapy.

Read Summary
Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)
ClinicalTrials.gov

Visceral Sensitivity in IBD (Irritable Bowel Disease) and IBS (Irritable Bowel Syndrome)

The study aims to clarify differences in visceral sensitivity and collect multiple biological samples that could help explain why some people with IBD have IBS-like symptoms. Findings could inform better symptom-targeted...

Read Summary
Postoperative monitoring in Crohn’s disease: A multimodal machine learning model for predicting early complications and endoscopic recurrence
Langenbeck s Archives of Surgery

Postoperative monitoring in Crohn’s disease: A multimodal machine learning model for predicting early complications and endoscopic recurrence

People with Crohn’s disease who have had, or will have, intestinal surgery may benefit from better tools to predict early complications and endoscopic recurrence. Predictive models could help tailor follow-up and...

Read Summary
Multimodal CCA + joint ICA reveals fused gray matter volume and resting-state functional alterations with neurotransmitter associations in Crohn’s disease
Journal of Translational Medicine

Multimodal CCA + joint ICA reveals fused gray matter volume and resting-state functional alterations with neurotransmitter associations in Crohn’s disease

This study links brain structure and function differences to clinical measures and neurotransmitter systems in Crohn’s disease, which may help explain cognitive, mood, or quality-of-life effects some people with CD...

Read Summary
Reviewer #1 (Public review): GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease
eLife Sciences Publications, Ltd

Reviewer #1 (Public review): GM-CSF regulates conserved ILC-like transcriptional states and myeloid cell signaling during ulceration in Crohn’s disease

The review evaluates a revised preprint linking GM-CSF, macrophages, and ILC-like cells in Crohn’s disease using human spatial transcriptomics and zebrafish experiments. It highlights limitations that matter because they...

Read Summary