Evidence types
Observational study articles covering real-world data, cohort studies, registries, and non-interventional IBD research.
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The study links common eating habits (fast food, fizzy drinks, spicy foods) with Crohn’s in this sample, which may help patients and clinicians think about dietary patterns worth discussing. It’s relevant because diet is...
Depression and IBD often co-occur; knowing that each can precede the other helps patients and clinicians monitor mental health and GI symptoms more proactively.
This study suggests a relationship between higher ustekinumab trough concentrations and clinical remission in adults with Crohn’s disease, which could be relevant to patients and clinicians considering drug-level...
The study links lower vitamin D and higher TNF‑alpha with greater UC severity and with each other, suggesting these measurable biomarkers may reflect inflammation in ulcerative colitis.
The study found higher recorded rates of hidradenitis suppurativa in people with Crohn’s disease and psoriatic arthritis, and a smaller increase in ulcerative colitis, suggesting clinicians should consider asking about...
This registry study offers real-world data on ozanimod effectiveness, persistence, and safety in UC patients, which can help patients and clinicians set expectations beyond clinical trial settings.
A sizable minority of people newly diagnosed with IBD—about 1 in 5 with Crohn’s and 1 in 10 with ulcerative colitis—received no IBD-specific drugs within the first year. Understanding who is untreated and why could...
This study describes how often people newly diagnosed with IBD go on biologic or JAK inhibitor therapy and what happened to them over five years — including hospital visits and surgery — which helps set expectations for...
The study suggests that using Advice & Guidance instead of elective referral was associated with a longer time to diagnosis for IBD, which could influence how primary care referral pathways are evaluated or designed.
This study raises pharmacovigilance signals and mechanistic hypotheses about liraglutide in people with ulcerative colitis — important because GLP-1 drugs are widely used and are being studied for inflammatory effects....
The study documents shifting real-world prescribing for newly diagnosed IBD in Germany, with more biologic use and less mesalazine/thiopurine in recent years — changes that could affect treatment expectations and access.
Patients and clinicians choosing among advanced therapies for ulcerative colitis may consider infection-related hospitalization risk as one factor; this study suggests lower risk with ustekinumab versus TNF antagonists...
The study suggests habitual diet that supports gut microbes may modestly lower the chance of developing IBD, especially ulcerative colitis, and links dietary patterns to blood protein changes tied to immune and...
Based on the title and source metadata, this appears to be an observational study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association...
Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Inflammatory bowel disease and Research and clinical trials.
CDI is a common and serious complication in people hospitalized with IBD. Understanding whether CDI independently increases the risk of death, ICU care, or surgery — or mainly drives longer stays and higher costs — helps...
Parents and clinicians often worry that when solids are started might change a child’s future risk of IBD. This large prospective study found no clear link between timing or patterns of complementary feeding and later...
This large real-world study found upadacitinib was associated with lower risk of treatment failure and more corticosteroid-free stability compared with several other advanced therapies for ulcerative colitis —...
If confirmed, genetic evidence that higher omega-3 levels or a lower omega-6/omega-3 ratio relate to lower Crohn’s disease risk could point to biological pathways worth studying and might guide research into prevention...
People with Sjögren syndrome or clinicians caring for them may be interested because genetic data suggest Sjögren syndrome could modestly raise gastric ulcer risk and — unexpectedly — associate with lower IBS risk, while...
Reported IBD rates in Brazil increased markedly between 2012 and 2025, which could mean more people will need diagnosis, specialist care, and medications. Rising numbers also matter for public-health planning and...
This study compares first‑line vedolizumab versus TNF antagonist strategies in biologic‑naive ulcerative colitis patients over multiple years — information that could affect treatment choice and expectations about...
Dose increases are common during IBD maintenance and vary a lot by drug and patient profile. Knowing which treatments and patient factors are linked to escalation can help patients and clinicians plan monitoring and...
The study documents substantial increases in Crohn’s disease and ulcerative colitis prevalence and changing incidence patterns in Northeastern Italy from 2012–2024, which may affect healthcare demand and resource...
The study suggests some autoimmune diseases common in IBD patients—ulcerative colitis and primary sclerosing cholangitis—may be genetically linked to higher pancreatitis risk. That could help researchers understand...
PSC commonly co-occurs with IBD in children; understanding clinical phenotypes and reliable monitoring tools helps families and clinicians track disease and plan follow-up.
Patients and clinicians often need real-world data on how methotrexate is actually used in IBD outside trials—this study shows it’s commonly paired with biologics, usually given subcutaneously, and has a median use of...
If validated, serum osmolality — a routine, low-cost blood measure — could become an additional marker to help identify IBD in certain hospitalized patients with anxiety. This could aid research and possibly improve...
Depression and GI diseases often co-occur; knowing which tends to appear first — and that this varies by subtype — can help clinicians prioritize screening and integrated care.
Knowing how IBD burden has changed over time and varies across states helps patients, clinicians, and health systems anticipate needs for diagnosis, specialized care, and resource planning. Rising Crohn’s burden in some...
Family history of CRC raises an individual’s absolute CRC risk whether or not they have IBD, and people with IBD who have multiple first‑degree relatives with CRC appear to have the largest increase in absolute risk....
Older adults (≥60) with IBD are an increasing population worldwide, and IBD-related anemia is rising—this affects screening needs, healthcare planning, and resource allocation. The findings point to widening...
Differences in urbanisation and socioeconomic development may help explain rising IBD rates in newly industrialised regions and point to where earlier diagnosis and healthcare planning might be needed. The association...
The findings highlight that older adults are less likely to be prescribed advanced IBD therapies, which could reflect prescribing patterns, comorbidities, insurance factors, or access issues relevant to treatment...
The study suggests that a simple, multidomain functional measure (intrinsic capacity) is linked to later IBD risk and that combining it with genetic risk may better identify people at higher risk—especially for Crohn’s...
Identifying common multimorbidity patterns and using machine learning to predict premature mortality could help health systems and clinicians prioritize integrated care for people with IBD, potentially improving outcomes...
This large, population-level analysis summarizes long-term global trends in IBD burden and shows rising incidence and persistent geographic and socio-demographic inequalities. Patients and clinicians may see why...
Corticosteroid use during IBD treatment periods was associated with higher rates of serious infections across drug classes and age groups, which may affect decisions about steroid use and infection-prevention planning.
The study suggests that modifiable early-life factors (breastfeeding, diet, antibiotic exposure, etc.) may be linked to later IBD risk, especially Crohn's disease. That could inform future prevention research and...
Researchers report a modest association between higher estimated dietary sodium and greater odds of several IL-17–mediated diseases, while IBD showed a small inverse association. Patients may be interested because it...
People with IBD and their clinicians may want to be aware of possible higher rates of some non-gastrointestinal cancers (thyroid, kidney, prostate) and of factors linked to higher risk such as long-term steroid use,...
Patients diagnosed with IBD during or shortly after emergency hospital care had substantially worse 1-year outcomes in this large, population-based analysis — highlighting that late or emergency presentation is linked to...
CDI is a serious infection that raises the risk of death for people with IBD. This study shows mortality linked to IBD+CDI changed over the last 25 years and that racial, geographic, and urban–rural disparities...
A validated claims-based algorithm could enable larger, more efficient studies of fibrostenosis in Crohn’s disease using real-world data — helping researchers and clinicians better measure how often stricturing...
Comparative real-world data may help patients and clinicians weigh expected benefits and risks of risankizumab versus ustekinumab in Crohn’s disease, including effects on steroid-free remission and fistula healing.
Compares widely used modelled GBD rates with population-based observations and finds they are not interchangeable for country-year estimates—important for research, surveillance, and policy that rely on these numbers.
Pregnant people with Crohn’s disease are often prescribed disease‑modifying therapies, yet clinical trial data in pregnancy are limited. Understanding real‑world medication use and potential drug–drug interactions helps...
If confirmed, the results suggest early-life exposures that perturb the gut microbiome may influence later risk of spondyloarthritis, which could be relevant for parents and clinicians weighing risks and benefits of...
