Keep up with the latest Crohn's and UC developments.
Meeting highlights summarize several studies that could affect treatment choices for Crohn’s disease and IBD — including positive data for risankizumab and investigational oral IL‑23 therapy, plus signals that guselkumab...
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Histologic inflammation on biopsy appears closely linked to what doctors see on endoscopy and, to a lesser degree, to symptoms and how much colon is involved. For families and clinicians, this suggests biopsy-based...
Baseline mucosal gene-expression patterns were associated with later response to JAK inhibitors in UC, which could eventually help predict treatment benefit and illuminate relevant immune pathways.
Local delivery can concentrate therapy at the site of inflammation (for example the gut in IBD) and may overcome limitations of systemic treatments. Framing delivery design around local exposure could lead to more...
Understanding commensal-specific T cells may help explain immune drivers of inflammation in IBD and could point to new biomarker or therapeutic targets in the future. For patients, this helps explain why immune responses...
Researchers are studying plant-derived polysaccharides as potential functional-food ingredients that may influence inflammation, gut barrier function, and the microbiome — processes relevant to ulcerative colitis.
The trial shows a targeted diet can lower fecal calprotectin, a biomarker of intestinal inflammation, in people at higher risk for Crohn's disease. If sustained, dietary modulation of inflammation could be a non-drug...
This study suggests vonoprazan — a potassium-competitive acid blocker usually used for acid-related disorders — showed protective effects in a mouse model of ulcerative colitis through antioxidant, anti-inflammatory, and...
Finding IL‑10–neutralizing autoantibodies identifies a specific, potentially treatable cause in a subset of IBD patients and explains a long‑standing genetic risk signal, which could lead to more precise diagnosis and...
This preclinical study suggests that cholic acid and related compounds can reprogram pro-inflammatory Th17 cells toward anti-inflammatory IL-10–producing cells and reduce experimental colitis, pointing to a potential new...
This study identifies a fibroblast state tied to inflammation in both Crohn’s disease and ulcerative colitis and shows that restoring TCF21 in cells can reduce inflammatory signals, pointing to a new stromal-focused...
This study suggests quercetin reduced inflammation and tissue-damage signaling in experimental ulcerative colitis models, highlighting a potential mechanism (ERK–MMP) that could inform future preclinical work. If...
This grant-funded study aims to find whether exposure to “forever chemicals” (PFAS) is associated with biological changes that occur before Crohn’s disease or ulcerative colitis are diagnosed. If links are found and...
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease and Procedures and surgery. The original article is from Updates in surgery.
People with ulcerative colitis and their clinicians are interested in biomarkers that might predict who will respond to vedolizumab, an anti-integrin biologic. This study explored mucosal gene-expression signals but did...
Based on the title and source metadata, this appears to be a low information aggregator related to Inflammatory bowel disease and Research and clinical trials. The original article is from msn.com.
New and longer-term data presented at ACG 2026 may expand treatment options for Crohn’s disease, including an oral IL-23–targeted peptide and potential effects of guselkumab on intestinal strictures, which could affect...
An at-home subcutaneous induction option for risankizumab could make starting Skyrizi easier and more convenient for adults with moderate-to-severe Crohn’s disease, potentially reducing the need for clinic infusions.
The study suggests more people in Spain are living with IBD even though new cases each year are stable, meaning healthcare systems may face increasing long-term care needs and resource demands.
Vulvar Crohn's can be the first or sole early sign of pediatric Crohn's disease and is often misdiagnosed, causing delays that risk permanent tissue damage. Recognizing the link prompts appropriate GI evaluation and...
The study suggests stool microRNA panels could become noninvasive tools to help diagnose pediatric Crohn’s disease and ulcerative colitis and to predict short‑term treatment response and 12‑month relapse risk, which...
Wearables and AI could let people with Crohn’s disease and IBD be monitored continuously at home, potentially detecting inflammation earlier, forecasting flares, and helping distinguish inflammatory from noninflammatory...
Based on the title and source metadata, this appears to be a guideline related to Inflammatory bowel disease and Tests and monitoring. The original article is from Korean Journal of Gastroenterology.
The review links persistent inflammation in IBD to epigenetic changes that could raise colorectal cancer risk and explains why current evidence is not yet ready to change surveillance or prevention practice.
The study suggests a natural flavonoid (jaceosidin) can reduce experimental colitis in mice by changing gut microbes and increasing a tryptophan metabolite (5‑HIAA) that promotes regulatory T cells through the AhR...
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Procedures and surgery. The original article is from Updates in Surgery.
This study will collect real-world data on how people with moderate-to-severe ulcerative colitis do after starting etrasimod, including symptom changes measured by patient questionnaires. That information can help...
This trial could directly influence which biologic class doctors choose first for people with ileal‑dominant Crohn’s disease by comparing approved treatments head‑to‑head using an important outcome — steroid‑free...
Strictures are a common, clinically important complication of Crohn's disease that can cause obstructive symptoms and sometimes lead to endoscopic dilation or surgery.
Researchers hope to identify which donor microbes and host factors determine whether FMT microbes take hold, and whether engraftment predicts clinical benefit in conditions including recurrent C. difficile infection and...
An at-home Skyrizi induction option can make starting risankizumab more convenient and reduce infusion-center visits for many adults with Crohn's disease. The approval is based on a phase 3 trial showing higher...
If baseline infliximab clearance and early trough levels predict poor outcomes, clinicians could identify people unlikely to reach remission early in induction and consider dose changes or closer monitoring sooner. That...
People with suspected IBD or clinicians working where fecal calprotectin testing is unavailable may be interested because the study explores simpler endoscopic signs and routine blood indices as an alternative way to...
A biosimilar to ustekinumab (Stelara) reaching more markets could increase access and lower cost for people with Crohn's disease, ulcerative colitis, and other immune-mediated conditions where ustekinumab is used.
The study suggests Aeromonas species are more frequently detected and at higher abundance in people with IBD versus non-IBD patients, and are associated with inflammatory markers — a finding that could point to a...
If you have IBD and also obesity or type 2 diabetes, GLP-1 drugs — commonly used for those conditions — might influence IBD-related outcomes according to early research. Understanding potential benefits and limits could...
Opportunistic infections like histoplasmosis can mimic Crohn's flares or cancer in immunosuppressed patients; missing them can delay appropriate antifungal treatment.
Bowel urgency is a common, distressing symptom in UC that harms quality of life. This phase 3b study reports that mirikizumab treatment was associated with notable reductions in urgency and improvements in multiple QoL...
Noninfectious skin lesions can occur during ustekinumab treatment for Crohn's disease and may require dermatology care; patients with prior anti-TNF–induced skin reactions appear at higher risk for psoriasiform...
Genetic variants (especially NUDT15) can raise the risk of dangerous low blood counts from thiopurine drugs. Knowing a patient's genotype before starting azathioprine/mercaptopurine could help prevent myelosuppression.
Based on the title and source metadata, this appears to be a guideline related to Inflammatory bowel disease and Pregnancy and fertility. The original article is from The Korean Journal of Gastroenterology.
Based on the title and source metadata, this appears to be a guideline related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from The Korean Journal of...
The study quantifies how often balloon delivery problems occur during EBD for Crohn's strictures and identifies modifiable procedural factors linked to those problems, which could help reduce procedural complications.
People with IBD, especially older adults on biologic immunosuppression, may be at higher risk for unusual bloodstream infections and complications such as possible endocarditis. Awareness can prompt timely imaging, blood...
The report highlights a rare transient neuro-ophthalmic event occurring shortly after infliximab infusion, which may be important for patients and clinicians using anti-TNF therapy to recognize and evaluate.
People with Crohn’s disease often lose lean muscle and struggle with nutrition; a widely available supplement like creatine could be an accessible way to support muscle mass and function if proven effective and safe. The...
Emergency surgical complications can occur in Crohn's disease and may require debridement, relaparotomy, colectomy, and colostomy. Recognizing Crohn's disease among acute abdominal presentations and relying on histology...
New or unusual skin lesions in people with Crohn’s disease can signal immune‑related skin disease that may be linked to the underlying IBD, biologic therapy, or recent infections. Recognizing PNGD can prompt appropriate...
