Evidence types
Animal study articles covering preclinical IBD research, disease mechanisms, microbiome work, and early treatment science. Research context emphasizes studies, trials, biomarkers, mechanisms, and emerging IBD science.
43 articles
This preclinical study describes a new cell‑based approach — macrophages engineered to secrete IL‑10 — that reduced inflammation and improved colon outcomes in a mouse colitis model, suggesting a potential avenue for...
An experimental mouse study suggests gastrodin may reduce colitis severity and associated anxiety/depression-like behaviours while changing gut microbiota, metabolites, and intestinal inflammation — an early preclinical...
The study links an experimental treatment (dexpanthenol) to reduced inflammatory cytokines and improved anxiety-like behaviors in a rat colitis model, which is relevant to research on inflammation-driven gut–brain...
The study suggests L‑proline can reduce colitis in a mouse model and reshapes the gut microbiome, raising the possibility that amino-acid–based dietary strategies might influence intestinal inflammation through...
Preclinical research suggests acebrophylline might reduce inflammation and oxidative stress in an experimental mouse model of ulcerative colitis, which could be an early step toward new treatments that target multiple...
The study tests combined neutralization of two pro-inflammatory cytokines plus IL‑10 in a mouse colitis model and reports reduced inflammation and restored macrophage cellular pathways, which may inform future IBD...
People with IBD are at increased risk of bone loss; this study points to a microbiome-related pathway (A. muciniphila and an IDA metabolite) that might protect bone in an experimental colitis model, which could...
The gut–liver axis links intestinal inflammation to liver disturbances in IBD. This preclinical study suggests a specific oat β‑glucan fraction reduced liver oxidative stress and inflammation in rats with chemically...
An animal study found two probiotic strains reduced inflammation and inflammasome markers in an experimental ulcerative colitis model, which could inform veterinary treatments and early-stage research relevant to IBD.
This preclinical study suggests a heat‑inactivated probiotic strain reduced colitis signs in mice and changed gut microbes and inflammatory pathways—findings that could inform future research into microbiome‑based or...
A reproducible animal model of perianal fistulizing Crohn’s disease could help researchers study how fistulas form and persist and provide a test platform for new therapies before human trials.
The study uses a mouse model of ulcerative colitis to test hemp seed oil and reports molecular and metabolic changes alongside reduced disease in the model. Patients and researchers may be interested because it explores...
Undernutrition and lean-mass loss are common and harmful in people with IBD. If dietary strategies can prevent weight and muscle loss and shift the gut microbiota toward SCFA producers, that could be relevant to...
People with ulcerative colitis may be interested because the study explores a plant extract that reduced inflammation markers in a common animal model of colitis, suggesting a possible new avenue for drug discovery or...
A common heart drug, verapamil, reduced disease signs in a mouse model of colitis and altered inflammation and the gut microbiota — suggesting a possible avenue for future IBD research. These are preclinical results, so...
The study raises the possibility that perinatal exposure to nanoplastics could have lasting, sex-specific effects on gut health and make adult offspring more susceptible to intestinal inflammation. This may be relevant...
People with IBD are often interested in how dietary fibers and the microbiome might influence inflammation.
Preclinical results suggest a fermented yak milk–derived probiotic strain may protect against colitis in mice by improving barrier function, lowering inflammatory cytokines, and changing the gut microbiome—mechanisms...
This study points to a plant-derived extract delivered in nanocarriers that reduced colon injury in a rat model of colitis, suggesting a potential route to targeted anti-inflammatory therapy that might avoid systemic...
Researchers are exploring natural compounds that might reduce intestinal inflammation and rebalance the gut microbiome. If translatable to humans, such approaches could inform new treatments or adjunctive therapies for...
This preclinical study suggests Antarctic krill oil may reduce inflammation and alter the gut microbiome in a mouse model of ulcerative colitis, which could point toward microbiota-targeted nutritional strategies worth...
This animal study suggests date palm pollen extract reduced inflammation and tissue damage in a rat model of colitis, which could point to new lines of research into dietary supplements or natural compounds for gut...
The study suggests a rice bran plus feruloyl-esterase–producing bacterium reduced inflammation and tissue injury in a mouse model of ulcerative colitis, pointing to a possible diet–microbiome approach worth further...
If you follow IBD research, this study suggests a heat-stabilized (nonviable) multi-strain bacterial product reduced inflammation and improved some disease measures in a mouse model of ulcerative colitis — a step that...
This animal study suggests Antarctic krill oil may reduce inflammation and weight loss in a mouse model of ulcerative colitis and works alongside changes in gut microbiota and metabolites—findings that could inform...
The study suggests a rice bran extract might reduce colitis severity in rats by shifting gut microbiota and dampening TLR4/NF-κB–driven inflammation, a pathway relevant to human IBD research.
This study suggests noninvasive vagus nerve stimulation (taVNS) can reduce colonic inflammation and change immune signals regionally in a mouse model of ulcerative colitis—supporting a possible neuroimmune approach worth...
A reproducible large-animal colitis model could improve preclinical testing by better mimicking human gut anatomy and immune responses than rodent models. That may help translational research and therapy evaluation for...
The study investigates how specific gut bacterial strains can change colitis severity in experimental models — important because microbes are a focus of IBD research and potential therapies.
The study links a common environmental pollutant (UV-328) to worsened experimental colitis and altered cholesterol metabolism, suggesting environmental exposures might influence IBD activity and could point to new...
The study identifies Gardenia-derived pectic polysaccharides that reduced inflammation and restored colon health in a mouse colitis model, suggesting a possible microbiome-mediated protective effect relevant to IBD...
This preclinical study reports that an extract of Anacyclus pyrethrum reduced colitis signs in a mouse DSS model and was linked to improved intestinal barrier markers, lower innate immune receptor expression, changes in...
The study suggests a new experimental compound (7-KC delivered in mβCD) reduced colitis severity in an acute mouse model, which could inform early-stage therapeutic research targeting immune cell membrane properties.
If findings translate to humans, creatine might help protect the gut lining and blood vessels during flare and remission, potentially supporting recovery of gut barrier function in ulcerative colitis.
This preclinical study suggests quince gel reduced inflammation, oxidative stress, and tissue injury in a rat model of ulcerative colitis and identifies quercetin as a likely active component. Findings point to possible...
This study suggests the cancer drug lapatinib reduced colon damage and liver changes in a rat model of chemical colitis, which could point to new research directions for IBD treatments or gut–liver injury mechanisms.
Researchers used a standard mouse colitis model to show a traditional herbal formula reduced inflammation and improved gut barrier markers, implicating the IL-33/ST2 immune pathway. This could guide future preclinical...
The work links intestinal inflammation with neurobehavioral changes in a mouse colitis model and suggests certain p‑coumaric acid derivatives can reduce inflammation and anxiety/depression‑like behaviors, which could...
This study identifies a plant-derived polysaccharide (from the stem of Dendrobium huoshanense) that reduced inflammation and tissue injury in a mouse model of ulcerative colitis and points to GLP-1 signaling as a likely...
This preclinical study suggests an herbal capsule formulation reduced colitis severity and shifted markers of oxidative stress, inflammation, and ferroptosis in mice — signaling possible biological pathways for future...
The study identifies a food-processing method (black tea processing) that increased flavonoids and improved outcomes in a mouse model of colitis, suggesting that specific dietary preparations might influence gut...
The study identifies a plant extract that reduced colitis-like injury in mice and altered gut microbes and intestinal barrier markers, which could inform future preclinical work. For people with IBD, this is early-stage...
This study suggests a Crohn's genetic risk factor can change pregnancy-related gut microbiome shifts and increase inflammatory signals in mice — which could help researchers look for microbial biomarkers that predict...
