Cure8 research brief
CDI is a serious infection that raises the risk of death for people with IBD. This study shows mortality linked to IBD+CDI changed over the last 25 years and that racial, geographic, and urban–rural disparities persist—information relevant to patients, clinicians, and public-health planning.
Adult patients with IBD and their caregivers, clinicians who manage IBD and infections, public-health professionals, and researchers studying infection-related outcomes and health disparities in IBD.
This study analyzed U.S. death-certificate data (CDC WONDER) from 1999–2023 to describe trends in mortality among adults with inflammatory bowel disease (IBD) who had Clostridioides difficile infection (CDI) listed on the death record.
The authors report a gradual decline in age-adjusted mortality from 1999–2018, a sharp increase from 2018–2021 (coinciding with the COVID-19 period), and a plateau through 2023.
The paper highlights persistent disparities: higher mortality in men, higher rates in non-Hispanic White people overall but rising rates in non-Hispanic Black and Hispanic groups in recent years, and higher mortality in rural areas and in the Midwest by 2023.
The authors emphasize public-health priorities such as antibiotic stewardship and equitable access to care but note the study design cannot prove causation for the 2018–2021 increase. Because this is a population-level, death-certificate analysis, it describes broad trends and disparities rather than individual risk factors or treatment effects.
It does not report clinical trial data or interventions and cannot determine whether CDI directly caused each death when listed alongside IBD on death certificates.
Findings come from death-certificate (CDC WONDER) data and describe associations and trends at the population level. The authors note the temporal overlap with the COVID-19 pandemic but the study cannot establish cause-and-effect. Death-certificate data can be limited by coding practices and cannot always determine whether CDI was the direct cause of death.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
People with both IBD and another immune-mediated disease (psoriatic disease) had more hospital admissions and higher inpatient costs over ten years in this population.
The paper reports that hospitalized people with IBD have a higher risk of heparin-induced thrombocytopenia (HIT) and that HIT is associated with worse outcomes (higher mortality, longer stays, higher costs, and more...
This large, population-based study suggests people with Crohn's disease have modestly higher overall mortality than matched controls and higher deaths from specific causes (colorectal cancer, renal disease, non-Hodgkin...
