World Journal of Gastroenterology
Cure8 research brief
Why This Matters
Fatigue affects many people with Crohn’s even when inflammation looks controlled; recognizing it as a distinct target could change clinic assessments and treatment priorities.
Who Should Pay Attention
Adults with Crohn’s disease or IBD, clinicians managing IBD, and researchers studying patient-reported outcomes, fatigue, or immune biomarkers.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This article reports an analysis that treated fatigue as a primary outcome and found it was not explained by common inflammatory markers (including CRP), anemia, nutritional deficits, or thyroid dysfunction. Psychological factors—especially when measured together (depression, anxiety, stress, insomnia)—greatly increased the risk of fatigue.
The study also found immune cell pattern changes (relative neutrophilia with lymphopenia/eosinopenia) linked to fatigue, suggesting stress-related immune activation may play a role.
Practical takeaways Fatigue in Crohn’s appears to be multidimensional and often independent of gut inflammation; clinicians and patients may need broader assessment (psychological screening, sleep assessment, and selected blood tests) and patient-centered management rather than relying solely on escalation of anti-inflammatory therapy.
Keep In Mind
Structured-content depth: abstract — the curation is grounded in the article abstract/summary provided by the journal. The study highlights associations but does not establish causation; practical management approaches were not tested as interventions in this report.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationWorld Journal of Gastroenterology
PublisherBaishideng Publishing Group Inc.
AuthorsTugce Eskazan, Suat Saribas, Bekir Kocazeybek
Study typeJournal Article
Indexed viaCrossref
Source typeResearch paper
PublishedJul 14, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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