ClinicalTrials.gov
Cure8 trial brief
TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)
Research and clinical trials
Infliximab
Adalimumab
Vedolizumab
Ustekinumab
Azathioprine
Mercaptopurine
Methotrexate
Why This Matters
A clear, reproducible definition of transmural healing on MRE could help standardize how deep healing is measured in Crohn's disease, which matters for tracking treatment goals and comparing study outcomes.
Who Should Pay Attention
Clinicians who interpret or order MRE for Crohn's disease, radiologists, researchers developing imaging biomarkers, and patients receiving biologics or immunomodulators who are interested in objective measures of deep healing.
Study Snapshot
Story typeClinical Reference
Evidence typeClinical trial
Enrollment320 participants
Study statusCompleted
Source depthTrial registry record
What To Know
The project focused on constructing an index (depth of remission) or grade (score) of transmural healing using statistical models applied to MRE features; intra- and inter-observer variability of radiologic findings and of TH definitions were prespecified secondary endpoints.
The registry lists broad eligibility (adult CD, any concomitant CD treatment allowed, including listed biologics and immunomodulators) and carefully excludes certain postsurgical and imaging-poor-quality situations. MRE exams performed as part of routine care were recorded and centrally reviewed rather than being experimental imaging procedures.
The study is observational and completed; the registry entry describes planned analyses and endpoints but does not report results or validated thresholds in this record. Interpret any clinical implications only after peer-reviewed publication or guideline incorporation.
Keep In Mind
This is a registry trial record (observational, completed) describing planned analyses and endpoints; the entry does not provide results. As an observational study using routine-care MRE, findings will depend on image quality and reader training; subsequent peer-reviewed publications are needed before changing clinical practice.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorGroupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Trial IDNCT05903066
Study typeObservational
Enrollment320 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedNov 4, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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