Cure8 research brief
Short periods of extreme heat may modestly increase the chance of hospitalization for IBD and Crohn’s disease. Patients and clinicians should be aware that temperature extremes could be a trigger for worsening disease and may contribute to health care use.
Adult patients with IBD (including Crohn’s disease), caregivers, clinicians managing IBD, and researchers studying environmental triggers or disease exacerbations.
This study used Korean national inpatient claims (2002–2023) and a time-stratified case-crossover design to examine short-term links between extreme temperature events and hospitalizations for 59 autoimmune diseases.
Heat waves—especially higher-intensity and consecutive-day heat—were more consistently associated with increased hospitalization risk than cold spells.
The strongest, FDR-significant associations were for inflammatory bowel disease overall and Crohn’s disease specifically: three consecutive days of heat-wave exposure at high percentile thresholds were associated with modestly higher odds of hospitalization.
The paper notes larger heat-related associations in men, people under 65, lower-income groups, and non-metropolitan residents, but interaction tests did not reach statistical significance. Authors recommend confirmation in other cohorts and investigation of mechanisms.
This brief summarizes the abstract provided by PubMed and does not represent a review of the full published article.
Findings come from an observational claims-based study in Korea using a case-crossover design; associations do not prove causation. Results were strongest for high-intensity, consecutive-day heat and retained significance after multiple-testing correction for IBD and Crohn’s disease, but the authors call for replication and mechanistic studies.
This summary is grounded in the article abstract provided on PubMed.
Review the original publication for the complete reporting, methods, and context.
Conflict statement: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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