Cure8 research brief
Pregnancy causes normal changes in common lab tests that can look like IBD activity. Understanding which tests remain reliable helps prevent unnecessary treatment changes and anxiety during pregnancy.
Pregnant patients with Crohn's disease or ulcerative colitis, their care teams (gastroenterologists and obstetricians), and researchers focused on IBD biomarkers in pregnancy.
The authors reviewed 68 pregnancies from a registry and compared lab values from before conception to each trimester and postpartum. They found that several typical inflammation-related labs (ESR, white blood cell count, some iron measures, albumin) changed across trimesters in ways consistent with normal pregnancy physiology.
Fecal calprotectin was reported as the only marker that remained stable throughout pregnancy, suggesting it may be the most reliable indicator of gut inflammation during pregnancy.
Results come from an abstract-summary of a registry-based study; most participants were on biologics and sample size was limited. Fecal calprotectin was the only stable biomarker reported, but clinical decisions should still integrate symptoms and specialist judgment.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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