Digestive diseases and sciences
Cure8 research brief
Why This Matters
This is relevant because many younger women with iron deficiency anemia are considered for upper and lower endoscopy to find bleeding sources or other causes. The study shows common diagnostic codes recorded after bidirectional endoscopy but does not prove these procedures improved diagnosis or care.
Who Should Pay Attention
Clinicians who manage iron deficiency anemia, gastroenterologists, researchers using EHR data, and adult female patients (18–44) facing evaluation for iron deficiency anemia.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This study looked at electronic health records for women aged 18–44 with laboratory-confirmed iron deficiency anemia who underwent same-day colonoscopy and upper endoscopy.
The authors report the frequency of recorded GI diagnostic codes within three months after the procedures, including gastritis/duodenitis, hemorrhoids, benign colorectal neoplasm codes, Helicobacter pylori, and inflammatory bowel disease (IBD) codes.
They emphasize that coded diagnoses in records do not necessarily represent newly discovered causes of iron deficiency anemia, and that without a comparison group who did not undergo endoscopy the study cannot determine whether routine same-day bidirectional endoscopy is beneficial.
The study is a retrospective EHR (TriNetX) cohort from multiple US healthcare organizations; findings reflect recorded diagnostic codes rather than confirmed new diagnoses or causal attribution. The authors performed a sensitivity analysis excluding patients with prior IBD codes, which reduced but did not eliminate post-procedure IBD coding. Limitations to
Keep In Mind
The report is an abstract-level journal article based on retrospective EHR coding data; coded diagnoses may reflect prior history or incidental findings rather than newly identified causes of anemia. The study design does not allow conclusions about benefit or yield of routine/endoscopic strategies.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationDigestive diseases and sciences
AuthorsDanny Aboujamra, Galvin Dhaliwal, Ashvin Dhaliwal +2 more
InstitutionMUSC Florence, Florence, SC, 29505, USA. aboujamr@musc.edu.
Study typeJournal article
Indexed viaPubMed
Source typeResearch paper
PublishedOct 7, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: Declarations. Competing interests: The authors declare no competing interests relevant to this work. Ethics approval: This study used aggregate, deidentified TriNetX output without access to patient-level records or protected health information. Consent to participate: Not applicable. Consent to publish: Not applicable.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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