Intestinal Failure (New York, N.Y.)
Cure8 research brief
Why This Matters
Intestinal failure is a serious, often life-changing complication of Crohn’s disease; this review highlights ways to reduce its risk and outlines management options when it occurs.
Knowing common predictors and prevention strategies can help patients and clinicians prioritize treatments and perioperative care to preserve bowel length and function.
Who Should Pay Attention
Clinicians managing Crohn’s disease, surgeons who perform IBD operations, gastroenterology multidisciplinary teams, and patients at high surgical risk or with complex/penetrating disease.
Study Snapshot
Story typeClinical Reference
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This narrative review frames intestinal failure in Crohn’s disease as largely preventable by addressing three main pathways: progressive inflammatory destruction, cumulative surgical loss, and postoperative septic complications.
It emphasizes perioperative optimization (nutrition and infection prevention), early effective medical therapy to reduce inflammatory burden, bowel-sparing surgical techniques (including strictureplasty and the Kono-S anastomosis), and a multidisciplinary approach to established intestinal failure that includes parenteral nutrition, GLP-2 agonists, and consideration of intestinal reconstruction or transplantation for refractory cases.
The paper proposes a risk-stratification model and management algorithm to guide clinicians, highlighting predictors such as young age at diagnosis, penetrating disease behavior, upper GI involvement, short residual small bowel (<200 cm), cumulative inflammatory burden, and lack of biologic therapy.
This summary is based on the article abstract provided by the source.
Keep In Mind
This is a narrative review (abstract-level summary). It synthesizes existing evidence and proposes an approach but does not report a new clinical trial. Recommendations reflect current literature as interpreted by the authors; individual treatment decisions should be made with clinicians.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationIntestinal Failure (New York, N.Y.)
AuthorsShah D, Alzamani M, Sehgal T +2 more
Study typeReview, journal article
Indexed viaEurope PMC
Source typeResearch paper
PublishedOct 23, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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