Cure8 research brief
This paper explores whether polygenic risk scores (PRS) predict key long-term outcomes after IBD diagnosis — notably intestinal surgery — which could be relevant for risk stratification research and future clinical tools if validated.
Researchers in IBD genetics, clinicians involved in long-term IBD care or risk stratification, and patients interested in genetics and prognosis.
The authors report that higher PRS for Crohn’s disease was associated with a higher risk of future intestinal surgery (per 1-SD higher PRS and comparing high vs low tertiles). Associations between PRS and gastrointestinal cancer or mortality were not significant for CD, and PRS associations in UC were nonsignificant after multiple-testing correction.
The study used UK Biobank data, adjusted for clinical covariates (disease duration, CRP, prior surgery, baseline medication use, demographics, lifestyle), and applied multiple imputation and FDR correction. The authors explicitly state these associations do not establish clinical utility and require external validation.
Findings are from UK Biobank observational data and the authors caution they do not establish clinical utility; external validation is required before PRS could inform care.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, China, award Z2024LC005; 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University, award ZYGD23013; National Natural Science Foundation of China, award 82470550, 82070560
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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