Cure8 trial brief
The record concerns a planned surgical approach using a patient's own bone marrow–derived stem cells to try to heal fistulating perianal Crohn's disease—an often hard-to-treat complication that substantially affects quality of life.
It may be of interest because it tests a rapid intraoperative preparation method intended to make autologous cell therapy more accessible.
Patients with fistulating perianal Crohn's disease; colorectal surgeons and gastroenterologists managing complex perianal disease; researchers and clinicians interested in stem‑cell therapies for IBD.
The study proposed to collect bone marrow in theatre, process it with a rapid preparation system, and inject the prepared autologous stem cells into the fistula tract during surgery. Participants would have baseline and follow-up clinical assessments and questionnaires (HBI, PCDAI, Short IBD) at planned visits up to 6 months.
The record notes the trial was withdrawn and was intended as a feasibility assessment rather than a definitive efficacy trial.
This is a ClinicalTrials.gov trial record describing a planned feasibility study. The registry lists the study as WITHDRAWN, so no outcomes are reported here. The entry outlines procedures and questionnaires but does not provide results.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Perianal fistulas are a serious complication of Crohn’s disease with limited high-quality trial evidence. This randomized trial suggests ustekinumab may increase the chance of combined clinical and MRI remission at 12...
Perianal fistulizing Crohn’s disease causes delayed healing and high recurrence after surgery. This study suggests a specific time-guided external traditional therapy may speed wound healing, reduce inflammation, and...
People with IBD who also have bleeding disorders face special risks during endoscopy, surgery, and when using immunosuppressive drugs. This case shows that coordinated care and hemostatic support can allow diagnosis and...
