PubMed Central
Cure8 research brief
Why This Matters
People with immune-mediated disease, prior transplants, or those taking strong immunosuppression may care because this report links recurrent airway ulceration after lung transplant to an autoimmune-like process that responded to a TNF‑α blocker (infliximab).
Who Should Pay Attention
Clinicians managing post-lung-transplant patients, pulmonologists, transplant teams, and patients on or considering biologic (anti‑TNF) therapy; researchers interested in extraintestinal manifestations of IBD-like disease.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthMetadata only
What To Know
This case report describes a patient with cryptogenic ulcerative tracheobronchitis who developed bronchial web–like stenoses requiring bilateral lung transplantation, then experienced recurrence of ulcerative tracheobronchitis six years post-transplant.
The recurrent airway disease shared histopathologic features resembling airway involvement of Crohn’s disease, though no gastrointestinal Crohn’s disease was documented after extensive evaluation. Clinicians treated the recurrence with the TNF-α inhibitor infliximab, and the report states the patient had rapid improvement with that therapy.
The report emphasizes uncertainty about the underlying autoimmune diagnosis and notes the need for careful monitoring because of augmented immunosuppression after starting infliximab.
This summary is based on the case report text published in Case Rep Transplant; it does not constitute medical advice and does not establish effectiveness beyond this single reported case.
Keep In Mind
This is a single case report describing a rare airway disease and its response to infliximab; it does not prove causation or generalizable effectiveness. The patient had no confirmed gastrointestinal Crohn’s disease despite similar airway histology. Treatment decisions involved weighing increased immunosuppression risks.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationPubMed Central
JournalCase Rep Transplant
AuthorsBrookes, Samuel, Sarkar, Paroma, Crowhurst, Thomas +6 more
Indexed viaPubMed Central
Source typeResearch repository record
PublishedAug 27, 2026, 12:00 AM
Content availableMetadata only
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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