NIH RePORTER
Cure8 regulatory brief
Why This Matters
Bile acids shape immune signaling in the gut, and this project investigates how altered bile acid pools during ileitis could contribute to Crohn’s disease—knowledge that might point to new biomarkers or treatment strategies.
Who Should Pay Attention
Researchers, clinician-scientists studying IBD pathogenesis, and patients interested in basic research on Crohn’s disease mechanisms
Study Snapshot
Story typeRegulatory
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
The team is measuring intestinal bile acid pools in mice and building computational models to quantify contributions from hepatic synthesis, ileal absorption (ASBT/SLC10A2), and microbial metabolism.
Preliminary data link Crohn’s-like ileitis and reduced, more pro-inflammatory bile acid pools; the investigators hypothesize that cytokine-driven downregulation of ileal bile acid uptake precedes visible tissue damage and helps drive immune dysfunction. These are preclinical, mechanistic studies in mice using genetic models and computational approaches.
The project aims to generate new paradigms that could point to biomarkers or therapeutic targets but does not report a clinical treatment or patient intervention.
Keep In Mind
This is a project-record describing ongoing, funded preclinical research in mice with computational modeling; it does not present clinical trial results and early findings are preliminary.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsDouglas Kojetin, Mark Scott Sundrud
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedJul 1, 2026, 12:00 AM
Content availableResearch project record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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