CEN Case Reports
Cure8 research brief
Why This Matters
This report links a rare kidney disease (FGN) with ulcerative colitis in a young adult and raises atypical familial Mediterranean fever as a possible underlying autoinflammatory cause; recognizing this could change evaluation and lead to colchicine treatment that appeared to help both kidneys and gut in this patient.
Who Should Pay Attention
Patients with IBD (especially unusual disease features or early-onset kidney disease), nephrologists, gastroenterologists, and clinicians interested in autoinflammatory disorders
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthMetadata only
What To Know
This is a single case report describing diagnosis of FGN by electron microscopy and DNAJB9 immunostaining in a 22-year-old woman with ulcerative colitis.
Because FGN is uncommon in young adults, the clinicians considered an underlying autoinflammatory disorder (atypical FMF) and treated with colchicine in addition to renoprotective therapy; bowel inflammation was also reported to improve after treatment adjustments.
The report highlights three practical points made by the authors: DNAJB9 immunostaining helps confirm FGN when ultrastructural features fit; FGN can present in younger patients and should prompt evaluation for systemic or autoinflammatory disease; and considering FMF in patients with intestinal lesions mimicking IBD may lead to colchicine therapy that could affect both renal and gastrointestinal manifestations.
Keep In Mind
Single case report: useful for hypothesis generation but not proof. DNAJB9 staining is a recognized marker for FGN; colchicine use here was based on suspected atypical FMF rather than randomized evidence.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationCEN Case Reports
PublisherSpringer Science and Business Media LLC
AuthorsAtsushi Sawase, Shinichi Abe, Kumiko Muta +12 more
Study typeJournal Article
Indexed viaCrossref
Source typeResearch paper
PublishedJul 30, 2026, 12:00 AM
Content availableMetadata only
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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