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Early-life animal exposure was not associated with risk of inflammatory bowel disease: a nationwide birth cohort study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Cure8 research brief

Early-life animal exposure was not associated with risk of inflammatory bowel disease: a nationwide birth cohort study.

2 min read
Research and clinical trials Clinical study Researchers Clinicians Parents Caregivers Newly Diagnosed Adult patients Inflammatory bowel disease

Why This Matters

This large, long-term study suggests that having pets or farm animals during pregnancy or early childhood probably does not meaningfully change a child’s later risk of developing IBD, which may reassure families concerned about animal exposure as a risk factor.

Who Should Pay Attention

Parents and caregivers considering pet or farm-animal exposure; researchers studying early-life environmental influences on IBD; clinicians counseling families about IBD risk factors.

Study Snapshot

Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract

What To Know

This Danish nationwide birth-cohort study followed about 90,000 offspring for a median of 24 years to see whether maternal-reported exposure to pets or farm animals before birth or in early childhood changed the child’s later risk of developing inflammatory bowel disease (IBD), Crohn’s disease (CD), or ulcerative colitis (UC).

The investigators found no clear association: neither prenatal nor early-life pet or farm-animal exposure was linked to higher or lower risk of IBD overall, and results were similar when CD and UC were analyzed separately. Exposure-window analyses that separated pregnancy-only and early-childhood–only exposure also did not show significant associations.

The study uses registry-confirmed IBD outcomes and long follow-up, which strengthens the findings. It reports adjusted hazard ratios close to 1.0 with confidence intervals that include no effect, supporting the conclusion that early-life animal exposure likely is not a major determinant of later IBD risk.

If you’re a parent wondering whether having pets or farm animals affects your child’s long-term IBD risk, this study provides reassuring evidence that such exposure was not associated with increased or decreased risk in this large Danish cohort.

Keep In Mind

This is an observational cohort from Denmark using maternal self-report for exposure and registry-based IBD diagnoses. As with all observational studies, residual confounding or differences in animal types, microbiomes, or geographic contexts could affect generalizability. The paper reports associations (not causal proof).

Source Details

Review the original publication for the complete reporting, methods, and context.

Read Original Source
Research paper Evidence type derived from source or registry metadata.
PublicationClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
AuthorsChristina Balmer, Manasi Agrawal, Anne Vinkel Hansen +4 more
InstitutionDepartment of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Centre for Preconception and Pregnancy in Autoimmune Diseases [PREG-AID], Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. Electronic address: chbalm@rm.dk.
Study typeJournal article
Indexed viaPubMed
Source typeResearch paper
PublishedOct 13, 2026, 12:00 AM
Content availableJournal abstract

This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.

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