Clinical radiology
Cure8 research brief
Why This Matters
If shorter, non-contrast MRE protocols can reliably show Crohn’s activity and strictures, patients could have faster scans with less gadolinium exposure. But if ulceration or penetrating disease is suspected, contrast-enhanced MRE may still be necessary.
Who Should Pay Attention
Clinicians and radiologists who order or interpret MRE for Crohn’s disease; adult patients with Crohn’s disease interested in imaging options; researchers studying imaging protocols.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This study suggests some abbreviated, non-contrast MRE sequences (including DWI) can detect Crohn’s disease activity, location and stenosis with high agreement compared with standard contrast-enhanced MRE, potentially reducing scan time and gadolinium exposure.
However, the non-contrast protocol performed less well for detecting ulceration and penetrating complications, so contrast-enhanced imaging may still be needed when those complications are a concern.
Because this is a retrospective single-centre study with a modest sample size and uses the report as the reference standard rather than an independent clinical or surgical gold standard, findings should be seen as preliminary and may need confirmation in larger, prospective studies.
Keep In Mind
Structured content depth: abstract. Retrospective single-centre study of 50 patients using the original report as the reference standard; results are encouraging but preliminary. Abbreviated protocol included BTFE, T2 SPAIR/TSE and DWI/ADC sequences. Contrast imaging remained better for ulceration and penetrating complications.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationClinical radiology
AuthorsMattio B, Korshunova M, Garlisi C +3 more
Study typeIm, journal article
Indexed viaEurope PMC
Source typeResearch paper
PublishedSep 5, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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