Clinical Journal of Gastroenterology
Cure8 research brief
Why This Matters
A drug (flucytosine) caused colitis that looked like an ulcerative colitis flare. Mistaking medication-induced colitis for IBD activity could lead to unnecessary changes in immunosuppressive treatment.
Who Should Pay Attention
Adult patients with ulcerative colitis or other IBD, gastroenterologists, infectious disease clinicians, and clinicians prescribing antifungal therapy (flucytosine/amphotericin B).
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthMetadata only
What To Know
The authors present a 56-year-old man with known ulcerative colitis who developed abdominal pain, diarrhea, and rectal bleeding after starting flucytosine with amphotericin B. Histopathology showed acute colitis.
Symptoms resolved rapidly after stopping flucytosine without changing underlying UC therapy, supporting a diagnosis of drug-induced colitis rather than an IBD flare.
The report highlights the diagnostic challenge of distinguishing medication injury from disease activity and suggests clinicians should consider recent or concurrent antimicrobials (including flucytosine) when IBD patients develop new/worsening GI symptoms.
Keep In Mind
Single case report — useful as a clinical reminder but not evidence of frequency or causation in broader populations. Full article is behind a publisher access control.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationClinical Journal of Gastroenterology
PublisherSpringer Science and Business Media LLC
AuthorsKevin Jia, Robert O’Neill, Christina Lee +2 more
Study typeJournal Article
Indexed viaCrossref
Source typeResearch paper
PublishedSep 6, 2026, 12:00 AM
Content availableMetadata only
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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