JACC. Case reports
Cure8 research brief
Why This Matters
Biologic therapy and steroid withdrawal were temporally associated with severe eosinophilic myocarditis in a patient with ulcerative colitis — a life-threatening but potentially treatable complication. Early recognition and biopsy-guided escalation to targeted therapies can be critical.
Who Should Pay Attention
Adults with ulcerative colitis on biologic therapy; clinicians treating IBD and acute heart failure; cardiology teams.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
A patient with UC and marked eosinophilia developed acute cardiogenic shock. Cardiac MRI and endomyocardial biopsy confirmed eosinophilic myocarditis. Initial treatment included veno-arterial extracorporeal membrane oxygenation and high-dose IV methylprednisolone.
Recurrent eosinophilia during steroid tapering led to use of mepolizumab, after which left ventricular function improved.
The authors highlight that in IBD patients on biologic therapy, new hypereosinophilia with acute heart failure should prompt consideration of eosinophilic myocarditis and early biopsy to guide escalation to targeted immunomodulatory therapy.
Keep In Mind
Single-patient case report; temporal association but not proof of causation. Mepolizumab was used as targeted therapy for recurrent eosinophilia during tapering; broader evidence for this approach is limited.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationJACC. Case reports
AuthorsJinyoung Lee, Darae Kim, David Hong +5 more
InstitutionDivision of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Study typeCase reports, journal article
Indexed viaPubMed
Source typeResearch paper
PublishedJun 18, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: Funding Support and Author Disclosures The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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