Cure8 research brief
Hepatitis E can cause elevated liver enzymes in people with IBD on biologics or small molecules. This series found infections were acute and resolved without chronic infection, and advanced therapy could be restarted. That's reassuring but based on a small number of cases.
Adults with Crohn's disease or ulcerative colitis on biologic or small-molecule (advanced) therapies; gastroenterology clinicians; pregnant patients with IBD.
This small case series reports 7 people with IBD (2 Crohn's, 5 UC) who developed hepatitis E infection while on biologic or small-molecule therapy.
In all cases the infection was detected after new elevations in liver enzymes, was asymptomatic or mild, and resolved without liver dysfunction; hepatitis E RNA became undetectable by week 12 and transaminases normalized (median ~4 weeks). Advanced IBD therapy was paused and later resumed without reported complications.
One pregnant patient had an uncomplicated course and a healthy delivery. The report is an abstract-level case series (no randomized comparison). It suggests that hepatitis E can present as transient transaminase elevations in immunosuppressed IBD patients and may not always progress to chronic infection, but numbers are small and follow-up is limited.
If you have IBD and rising liver enzymes while on advanced therapy, your care team may test for hepatitis E virus (serology and PCR) as part of the workup and may consider temporarily holding immunosuppression until viremia clears. This study does not replace individualized medical advice.
This is an abstract-level case series with seven patients; it describes short-term clinical course and virologic clearance but does not provide long-term follow-up or comparative risk estimates. The study was reported in JCC Plus (abstract-level content).
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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