Cure8 research brief
Patients with idiopathic uveitis or scleritis may have undiagnosed, subclinical intestinal inflammation. If serial fecal calprotectin reliably pinpoints those with subclinical ileitis, it could help target digestive evaluation to people most likely to benefit.
Clinicians (ophthalmologists, gastroenterologists), researchers studying IBD and extraintestinal manifestations, and adults with idiopathic uveitis or scleritis concerned about hidden gut inflammation.
This study followed 69 patients with idiopathic uveitis or scleritis and used baseline fecal calprotectin with a repeat test (at 3 months if positive, 6–12 months if negative) to define longitudinal patterns. Five of 62 evaluable patients (8.1%) had subclinical ileitis confirmed by capsule endoscopy and/or colonoscopy.
Baseline calprotectin was higher in those with ileitis and the second determination showed stronger discrimination; a persistent elevation pattern had high sensitivity and good specificity in this sample.
The study is exploratory and small: only five confirmed events, and some patient subgroups were not endoscopically verified, so the reported diagnostic metrics are provisional. The authors state that larger, prospective multicenter validation is required before recommending screening.
The cohort was small with only five confirmed ileitis cases; some calprotectin trajectory subgroups were not endoscopically verified. This is exploratory evidence and not a screening recommendation.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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