Cure8 research brief
Vitamin D deficiency was very common in this IBD cohort and was linked to Crohn’s disease and female sex, which may matter because deficiency can affect bone health and immune regulation in people with IBD.
Adult patients with Crohn’s disease or ulcerative colitis, clinicians managing IBD, and researchers studying nutrition, biomarkers, or immune factors in IBD.
This study measured serum 25-hydroxyvitamin D [25(OH)D] in 184 patients with inflammatory bowel disease (122 Crohn’s disease, 62 ulcerative colitis) and 410 non-IBD controls and compared concentrations by disease subtype and demographics.
Patients with IBD had substantially lower median vitamin D levels than controls and a high prevalence of severe deficiency (<25 nmol/L). Severe deficiency was associated with higher odds of IBD in both sexes, with a stronger association in females. Crohn’s disease patients had lower vitamin D concentrations than those with ulcerative colitis.
The report highlights a high rate of vitamin D deficiency in this IBD cohort, especially among people with Crohn’s disease and women. The authors call for larger prospective multicenter studies to clarify causes and clinical implications.
This is a cross-sectional comparative study from a tertiary center vs a population control cohort; it reports associations but cannot prove causation. The article is an abstract-level summary (structured content depth: abstract) and the authors recommend larger prospective studies to confirm clinical implications.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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