Cure8 research brief
Kidney dysfunction can occur in people with IBD and may be under-recognized. A validated prediction model could help clinicians identify IBD patients at higher risk and prompt earlier monitoring or interventions.
Adult IBD patients, gastroenterologists, nephrologists, and clinical researchers interested in IBD extraintestinal complications and risk prediction.
This open-access retrospective cohort study used hospital records to identify predictors of renal dysfunction (eGFR < 90 and < 60 mL/min/1.73 m2) among patients with inflammatory bowel disease and to build a predictive model validated internally and externally.
The authors report seven independent predictors including baseline eGFR, HDL, CRP, osteoporosis, biologic therapy, enteral nutrition, and prior intestinal surgery, and provide C-index performance for the model.
What the paper did: analyzed clinical and laboratory data from a training cohort (n=769) and external validation cohorts (n=298) to identify risk factors and to develop a Cox-based prediction model. The model performance metrics (C-index) are reported for renal insufficiency and chronic kidney disease.
How patients might use this: the model aims to help clinicians identify IBD patients at higher risk of declining kidney function so they can consider closer monitoring of renal function or mitigation of modifiable risks.
Limitations to watch for: this is a retrospective study from Chinese hospitals; applicability to other populations may vary and the study design cannot prove causation.
This is a retrospective cohort study with internal and external validation reported in BMC Gastroenterology. Findings are associative and reflect the studied hospitals/population; prospective validation in other settings would strengthen applicability.
Review the original publication for the complete reporting, methods, and context.
Funding disclosed by the source: "Pioneer" and "Leading Goose" R&D Program of Zhejiang, award No. 2025C02137
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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