Cure8 research brief
A blood biomarker that reflects transmural inflammation could help monitor small-bowel Crohn’s disease noninvasively and might predict risk of rehospitalization.
Adults with small-bowel Crohn’s disease; gastroenterologists and IBD clinicians; researchers focused on IBD biomarkers and imaging.
The article presents a prospective study linking a blood biomarker (LRG) with imaging-derived measures of transmural inflammation in small-bowel CD. The investigators compared LRG to fecal calprotectin and C-reactive protein and found LRG performed comparably to fecal calprotectin and better than CRP for detecting transmural activity.
The study used DBE-guided endoscopic ultrasonography to assess transmural inflammation. The study is published in World Journal of Gastroenterology and appears to be an in-press peer-reviewed prospective clinical study from a Chinese center.
The findings suggest LRG could be a useful noninvasive marker for transmural disease activity, but this is a single prospective study and further validation in larger, multicenter cohorts would be helpful.
This is an in-press prospective study from World Journal of Gastroenterology using DBE-guided endoscopic ultrasonography as the imaging reference. Findings require external validation and careful review of the full paper (methods, sample size, thresholds) before clinical use.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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