Cure8 research brief
A simple blood lymphocyte percentage could be a convenient, non-invasive marker to help distinguish endoscopic remission from active disease in both Crohn’s and ulcerative colitis; chemokines CXCL10 and CCL25 may also reflect activity in Crohn’s disease.
Clinicians and researchers interested in noninvasive biomarkers for IBD monitoring; adult IBD patients curious about less-invasive ways to track disease activity.
This is a single prospective observational study of 195 IBD patients (both CD and UC) admitted between March 2024 and November 2025.
The main finding presented in the abstract is that peripheral blood lymphocyte percentage discriminated contemporaneous endoscopic remission from activity with reported sensitivity and specificity; correlations with endoscopic scores were stronger for UC (negative correlation with UCEIS) than for CD (no correlation with SES-CD).
The authors also measured serum CXCL10 and CCL25 and found lower levels in remission CD patients compared with active CD, but no difference in UC.
Practical note The report frames peripheral lymphocyte percentage as a convenient, non-invasive indicator that could help estimate endoscopic status, but this abstract-level summary does not include full diagnostic thresholds, external validation, or comparison to established biomarkers (for example fecal calprotectin) in detail.
Clinicians and patients should view this as preliminary evidence that warrants further validation before changing monitoring strategies.
This classification and brief are grounded in the article abstract (European Journal of Medical Research).
The abstract reports patient numbers, associations, and that lymphocyte percentage discriminated endoscopic status, but does not provide full methods, thresholds, or external validation—so findings should be considered preliminary until read against the full paper and replicated.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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