ClinicalTrials.gov
Cure8 trial brief
Why This Matters
The trial is testing a personalized approach that uses CLE to find foods that directly disrupt the intestinal barrier and then removes those foods to see if patients feel and biologically improve. If successful, it could offer a targeted, test-driven dietary option for Crohn's patients who suspect food triggers.
Who Should Pay Attention
Adults with Crohn's disease who report food-related symptoms, gastroenterologists and endoscopists interested in CLE, nutrition researchers, and clinicians studying diet-based interventions in IBD.
Study Snapshot
Story typeClinical Reference
Trial phaseNA
Enrollment30 participants
Study statusRecruiting
Source depthTrial registry record
What To Know
The study enrolls ~30 Crohn's disease patients with suspected food-related symptoms. At baseline participants undergo endoscopy with CLE and an on-table food challenge to see if common foods (wheat, yeast, milk, soy, egg white) trigger a localized barrier defect.
Those with a CLE-detected reaction enter a two-stage, 6-month nutrition/lifestyle intervention: a 3-month stabilization phase on a mostly vegetarian Mediterranean wholefood diet plus lifestyle strategies taught during an initial inpatient program, followed by a 3-month elimination phase where the CLE-identified trigger food is avoided while maintaining the diet and lifestyle measures.
Participants will have optional repeat CLE with food challenge after each phase, provide blood, stool, urine, bile and biopsies, and complete symptom, quality-of-life and disease-activity questionnaires. Nutritional intake and symptoms are tracked in an app throughout the study.
Keep In Mind
This record is a clinical trial registration (interventional, recruiting) and describes planned procedures and outcomes rather than reported results. Confocal laser endomicroscopy is a specialized endoscopic technique used here as a diagnostic tool; wider availability and required expertise may limit immediate generalizability.
Source Details
Review the original publication for the complete reporting, methods, and context.
Clinical trial
Evidence type derived from source or registry metadata.
PublicationClinicalTrials.gov
SponsorUniversität Duisburg-Essen
Trial IDNCT06719778
Study typeInterventional
Trial phaseNA
Enrollment30 participants
Indexed viaClinicalTrials.gov
Source typeTrial registry record
PublishedOct 13, 2026, 12:00 AM
Content availableTrial registry record
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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