Inflammatory intestinal diseases
Cure8 research brief
Why This Matters
Some rare autoinflammatory disorders can look like IBD but need different diagnostic thinking. Recognizing systemic signs and checking serum zinc may lead to a correct diagnosis and targeted care.
Who Should Pay Attention
Clinicians evaluating atypical or refractory colitis, adult patients with unusual systemic findings plus colitis, and researchers interested in autoinflammatory causes of IBD-like disease.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
This article presents a single-patient case in which genetic testing (PSTPIP1 E250K) and characteristic lab findings (hyperzincemia) led to a diagnosis of PAMI syndrome after years of refractory colitis. The authors report that adalimumab treatment produced clinical and endoscopic remission in this patient.
The report highlights that serum zinc measurement is a low-cost screening test that may help identify PAMI in patients whose intestinal disease is unusual for typical IBD. The case underlines the value of looking for systemic clues (cytopenias, severe acne, hepatosplenomegaly) that point away from isolated IBD.
This is a single case report and does not establish how common this presentation is or prove that adalimumab is broadly effective for PAMI-related colitis.
Keep In Mind
This is a single case report (abstract-level summary). Findings are not generalizable; genetic confirmation and characteristic lab abnormalities supported the diagnosis here. Serum zinc was proposed as a screening/monitoring marker by the authors but requires broader validation.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationInflammatory intestinal diseases
AuthorsRodsaward P, Kiattikunrat K, Tangnuntachai N +2 more
Study typeJournal article, case reports
Indexed viaEurope PMC
Source typeResearch paper
PublishedJan 1, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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