Medication topics

Sulfasalazine

Sulfasalazine articles covering 5-ASA treatment, safety, access, and ulcerative colitis or broader IBD care decisions. Medication context emphasizes treatment decisions, safety, approvals, and therapy access.

8 articles

Design and Evaluation of Colon-Specific Epinastine Prodrugs as Potent Anti-Colitis Agents Acting via the Activation of the Nrf2−HO-1 Pathway
Molecular Pharmaceutics

Design and Evaluation of Colon-Specific Epinastine Prodrugs as Potent Anti-Colitis Agents Acting via the Activation of the Nrf2−HO-1 Pathway

The study presents a preclinical strategy to concentrate an existing antihistamine drug in the colon and reduce systemic exposure, which could improve local efficacy and safety for IBD treatment if later validated in...

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Drug Induced Myelosuppression and Alopecia Totalis in Ulcerative Colitis Patient: Unmasking the Enigma
Open Access Journal of Pharmaceutical Sciences and Drugs

Drug Induced Myelosuppression and Alopecia Totalis in Ulcerative Colitis Patient: Unmasking the Enigma

The report highlights a serious drug-related complication (pancytopenia/myelosuppression and hair loss) in a patient treated with azathioprine plus sulfasalazine for ulcerative colitis, suggesting clinicians and patients...

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Hepatic and splenic tuberculosis following infliximab therapy for refractory ulcerative colitis: a case report and literature review
BMC Gastroenterology

Hepatic and splenic tuberculosis following infliximab therapy for refractory ulcerative colitis: a case report and literature review

Extrapulmonary TB can be triggered or revealed during immunosuppressive biologic therapy and may mimic other causes of liver injury; early recognition and TB-specific testing are important for timely treatment and to...

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Sulfasalazine- and Cerium Ion-Loaded Polymersomes with Enhanced RONS Scavenging and Colonic Mucosal Repair Ameliorate Experimental Colitis.

The work targets oxidative/nitrosative stress and mucosal repair—mechanisms important in IBD—using a novel delivery vehicle that pairs an approved anti-inflammatory drug with catalytic cerium ions. If translated, this...

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