Ochsner journal
Cure8 research brief
Why This Matters
People with ulcerative colitis can rarely develop visceral pyoderma gangrenosum that mimics infection (for example, a splenic abscess). Recognizing this can prevent unnecessary invasive procedures and guide appropriate immunosuppressive treatment.
Who Should Pay Attention
Adult patients with ulcerative colitis, gastroenterologists, dermatologists, emergency and hospital medicine clinicians, and surgeons who evaluate sterile visceral lesions.
Study Snapshot
Story typeClinical Reference
Evidence typeResearch paper
Source depthJournal abstract
What To Know
A 58-year-old woman with ulcerative colitis developed abdominal pain and a hypodense splenic lesion interpreted as an abscess; cultures were negative. Percutaneous drainage was performed but cultures remained sterile and the patient developed cutaneous lesions.
Given the negative microbiology and skin findings, clinicians diagnosed pyoderma gangrenosum with visceral involvement and treated her successfully with infliximab. The report emphasizes careful consideration of noninfectious causes for sterile visceral lesions in patients with inflammatory bowel disease to avoid unnecessary or harmful interventions.
Clinical context: This is a single case report (abstract-level summary) describing an unusual presentation; it does not establish how often this occurs or compare treatments.
Keep In Mind
This is an abstracted case report; it describes one patient and does not provide comparative evidence. Visceral pyoderma gangrenosum is rare, and diagnosis often relies on clinical judgment and exclusion of infection. The article reports successful treatment with infliximab but does not establish effectiveness generally.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationOchsner journal
AuthorsRuiz NM, Ibarz JO, López SR +2 more
Study typeJournal article, case reports
Indexed viaEurope PMC
Source typeResearch paper
PublishedJan 1, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Transient sinus bradycardia complicating acute severe ulcerative colitis a case report and review of the literature
Severe ulcerative colitis can be linked to rare cardiac rhythm disturbances; recognizing bradycardia during flares may prompt appropriate evaluation and monitoring. The case signals clinicians to consider cardiac causes...
Sweet’s syndrome during anti-TNF therapy with successful rescue using a JAK inhibitor in refractory ulcerative colitis: a case report and literature review
People with UC can develop severe neutrophilic skin complications like Sweet’s syndrome that may reflect active bowel inflammation even when recent tests suggested remission.
Flucytosine-induced colitis mimicking a flare of ulcerative colitis: a diagnostic challenge in pulmonary cryptococcal infection
A drug (flucytosine) caused colitis that looked like an ulcerative colitis flare. Mistaking medication-induced colitis for IBD activity could lead to unnecessary changes in immunosuppressive treatment.