Cure8 trial brief
MR enterography is an important tool to measure transmural inflammation in ileal Crohn's disease, but many patients find the oral distension agents unpleasant. Demonstrating that non-distended MR enterography yields similar inflammatory scores could increase patient acceptability and testing frequency.
Adults with ileal Crohn's disease; gastroenterologists and radiologists; researchers interested in imaging biomarkers and patient-centered monitoring approaches.
This is a prospective, multicenter interventional concordance study enrolling adults with ileal ± colonic Crohn's disease who need reassessment of inflammatory activity.
Each participant will have two MR enterography exams 2–7 days apart: one without an oral distension agent and one with the usual distension product; both use the same MRI sequences and gadolinium contrast.
Images will be centrally reviewed by blinded expert radiologists and the primary endpoint is concordance of the Modified Clermont (C-) score assessed using Lin's coefficient.
This entry is a clinical trial record (recruiting) describing study design and endpoints; it does not report study findings. The primary outcome is concordance of the Modified Clermont score between two MRI methods. Participants will still receive gadolinium contrast for both scans.
Review the original publication for the complete reporting, methods, and context.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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