BMJ case reports
Cure8 research brief
Why This Matters
This case shows that routine pre-biologic screening can reveal other granulomatous disease (pulmonary sarcoidosis) that may affect treatment choice. It also illustrates that infliximab (an anti-TNF) was used with improvement in both Crohn's disease and pulmonary sarcoidosis in this single patient.
Who Should Pay Attention
Adult patients with Crohn's disease being evaluated for biologic therapy, pulmonologists and gastroenterologists involved in diagnostic workups, and clinicians considering anti-TNF treatment when granulomatous lung disease is present.
Study Snapshot
Story typeResearch paper
Evidence typeResearch paper
Source depthJournal abstract
What To Know
A man in his 30s with longstanding ileal Crohn's disease was found to have asymptomatic pulmonary sarcoidosis during routine pre-biologic screening. Transbronchial biopsies confirmed non-necrotising granulomas. Because of postoperative endoscopic Crohn's recurrence and the pulmonary findings, infliximab was chosen to treat both conditions.
The patient had endoscopic and histologic improvement of Crohn's and radiological improvement of pulmonary sarcoidosis on follow-up imaging. The report highlights diagnostic overlap of granulomatous diseases and describes a successful anti-TNF treatment strategy in this single case.
This is a single-case report (BMJ Case Reports) summarized from the article abstract. It describes diagnostic workup (lung function testing, CT imaging, transbronchial biopsy) and a treatment decision to use infliximab with subsequent improvement noted on endoscopy and CT.
It does not provide controlled evidence about safety or effectiveness of infliximab for both diseases beyond this patient.
If you or your clinician are considering biologic therapy and have unexplained lung findings, this case supports that detailed pulmonary evaluation and multidisciplinary discussion can be helpful, and that anti-TNF therapy has been used successfully in at least one reported patient with coexisting Crohn's and sarcoidosis.
Keep In Mind
This is a single case report summarised from the article abstract (BMJ Case Reports). Case reports can describe informative clinical experiences but do not establish effectiveness or safety for broader patient groups.
Source Details
Review the original publication for the complete reporting, methods, and context.
Research paper
Evidence type derived from source or registry metadata.
PublicationBMJ case reports
AuthorsEzaam Fraz, Phillip Minh Tien Karpati, Denis Rubtsov +4 more
InstitutionDepartment of Gastroenterology and Hepatology, The Prince Charles Hospital, Chermside, Queensland, Australia ezaam.fraz@health.qld.gov.au.
Study typeJournal article, case reports
Indexed viaPubMed
Source typeResearch paper
PublishedSep 28, 2026, 12:00 AM
Content availableJournal abstract
Conflict statement: Competing interests: None declared.
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
Perianal Crohn Disease in a Patient With Congenital Afibrinogenemia: A Multidisciplinary Therapeutic Management Challenge.
People with IBD who also have bleeding disorders face special risks during endoscopy, surgery, and when using immunosuppressive drugs. This case shows that coordinated care and hemostatic support can allow diagnosis and...
Report of Meckel Diverticulum Mimicking Stricturing Crohn's Disease in an Adolescent Boy
A Meckel diverticulum can present like Crohn’s disease and may be the true cause when IBD treatment fails; identifying it can lead to a surgical cure for symptoms such as anemia and obstruction.
Severe Chronic Anemia and Tumor-Mimicking Colonic Lesions as an Atypical Presentation of Crohn's Colitis
Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Infliximab, and Azathioprine.