NIH RePORTER
Cure8 regulatory brief
Why This Matters
Understanding whether innate lymphoid cells retain ‘memory’ that drives psoriasis relapse could reveal biomarkers to monitor recurrence and suggest new therapeutic targets for patients with recurrent disease.
Who Should Pay Attention
Researchers studying psoriasis, innate immunity, or immune memory; translational clinicians interested in biomarkers or new therapeutic targets for recurrent psoriasis.
Study Snapshot
Story typeRegulatory
Evidence typeFunded research project
Study statusFunded
Source depthResearch project record
What To Know
Project record from NIH Reporter describing a funded research project testing whether skin innate lymphoid cells (ILCs) with memory drive psoriasis relapse.
The team will use single-cell multiomics, adoptive transfer, and cell-specific knockout models in mice (aim 1) and single-cell sequencing of clinical patient samples (aim 2) to characterize ILC contributions and identify potential biomarkers and therapeutic targets. This is a project summary of planned and ongoing funded research, not study results.
It outlines aims, methods, and rationale focused on innate lymphoid cell memory and relapse mechanisms in psoriasis. The work includes single-cell/ATAC multiomics and translational sequencing of patient skin samples.
Keep In Mind
This is a funded project record describing planned experiments (mouse models and patient single-cell sequencing). It does not report results; findings will depend on study completion and peer-reviewed publication.
Source Details
Review the original publication for the complete reporting, methods, and context.
Funded research project
Evidence type derived from source or registry metadata.
PublicationNIH RePORTER
AuthorsLeone Sophia Hopkins
InstitutionOHIO STATE UNIVERSITY
Study typeFunded Research Project
Indexed viaNIH RePORTER
Source typeFunded research record
PublishedSep 28, 2026, 12:00 AM
Content availableResearch project record
Funding disclosed by the source: National Institute of Arthritis and Musculoskeletal and Skin Diseases - F32AR087217 - $84,580
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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