Cure8 research brief
Patients with ulcerative colitis may develop advanced neoplasia after seemingly complete endoscopic removal of dysplasia. Detecting genomic alterations in adjacent, histologically normal margins could identify higher-risk patients who might benefit from closer surveillance.
Clinicians treating ulcerative colitis (gastroenterologists, colorectal surgeons), researchers in IBD-associated cancer and biomarkers, and UC patients post-endoscopic resection of dysplasia.
The study analysed 51 UC patients who had endoscopic resection of dysplastic lesions and performed low-coverage whole-genome sequencing on dysplastic lesions and adjacent histologically non-dysplastic margins.
Margins from lesions that later progressed had higher somatic copy number alteration burden, and high margin CNA burden was independently associated with local progression in multivariable analysis.
This was a retrospective single-centre cohort using lcWGS to detect copy-number changes; it proposes genomic margin assessment as a potential biomarker to inform post-resection surveillance, not as a validated clinical test yet.
Preprint on medRxiv; retrospective single-centre cohort using low-coverage whole-genome sequencing. Results are preliminary and require prospective validation before being used to guide care.
Review the original publication for the complete reporting, methods, and context.
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