medRxiv
Cure8 research brief
Why This Matters
This study maps a shared transcriptional programme linking inflamed IBD tissue to colorectal cancer pathways, highlighting potential biomarker and prevention targets relevant to the inflammation-to-cancer transition.
Who Should Pay Attention
Researchers studying IBD-related carcinogenesis, translational scientists working on biomarkers or chemoprevention, and clinicians interested in IBD-associated colorectal cancer risk.
Study Snapshot
Story typeResearch paper
Evidence typePreprint
Study statusPreprint
Source depthJournal abstract
What To Know
This preprint reports a gene-expression analysis comparing IBD colon mucosa and colorectal tumors to identify a 120-gene “Dysbiosis-Hippo Response (DHR)” module that is concordantly dysregulated in both IBD and YAP-high CRC.
The DHR groups genes into three functional archetypes: innate immune activation, epithelial–mesenchymal transition (EMT) priming, and tumor microenvironment immune regulation.
The authors found that canonical YAP target genes strongly upregulated in CRC were not changed in IBD mucosa, suggesting the shared DHR programme acts through non-canonical YAP effectors. They propose the DHR module could point to biomarker and chemoprevention targets at the inflammation-to-cancer transition.
This is a preprint (medRxiv) and the structured content here summarizes the provided abstract; Cure8 has not reviewed the full peer-reviewed paper. Do not interpret this as clinical guidance.
Keep In Mind
This is a preprint (not peer reviewed) and the report is based on integrative transcriptomic analyses (bulk RNA-seq) from public cohorts. Findings are hypothesis-generating and require validation in independent cohorts and functional studies before clinical application.
Source Details
Review the original publication for the complete reporting, methods, and context.
Preprint
Evidence type derived from source or registry metadata.
PublicationmedRxiv
AuthorsNoor, S., Vignaish, K. S., Joshi, P.
Study typePublishaheadofprint
Indexed viamedRxiv
Source typePreprint
PublishedSep 26, 2026, 12:00 AM
Content availableJournal abstract
This Cure8 brief is based on source text from the linked article. Cure8 is informational only and is not a substitute for professional medical advice, diagnosis, or treatment.
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